Eye-concentrated distribution of dexamethasone carried by sugar-chain modified liposome in experimental autoimmune uveoretinitis mice

Biomedical Research
Yukio ArakawaNobuo Kurokawa

Abstract

Corticosteroid is generally accepted as a standard therapeutic agent for active inflammatory (and) autoimmune eye diseases. In an attempt to develop a system to deliver corticosteroid most efficiently to the target eye, a sialyl-Lewis X (sLe(x))-conjugated liposome was adopted as a candidate for a carrier of dexamethasone (Dexa) and tissue distribution of intravenous Dexa with the modified liposome as well as Dexa alone as control was studied in normal and experimental autoimmune uveoretinitis (EAU) mice. Intravenous Dexa (1 mg) was widely distributed in all the tissues (eye, brain, heart, lung, liver, kidney, spleen and intestine) examined in similar manner in both mice and Dexa concentration was lowest in the eye except the brain. The tissue concentrations of Dexa in EAU group were all significantly lower than those in the corresponding tissues in normal group. Intravenous Dexa (2 microg) in the modified liposome was almost concentrated to the eye in EAU mice, reaching 13.84 ng/mg tissue in contrast to 2.34 ng/mg tissue in Dexa (1 mg) alone administered EAU mice. In normal mice, Dexa was undetectable in any tissues examined and thus the effect of the modified liposome was not observed. The result supported the potentiality of...Continue Reading

References

Oct 1, 1985·Archives of Ophthalmology·G N ScholesM F Kubicek
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K NambaK Onoé
Sep 12, 2002·Biochimica Et Biophysica Acta·David C Kilpatrick
Feb 19, 2004·Advanced Drug Delivery Reviews·Carsten EhrhardtUdo Bakowsky
Mar 24, 2004·International Immunopharmacology·M R Namazi
Jul 15, 2006·Current Rheumatology Reports·Russell W Read
Dec 21, 2006·Japanese Journal of Ophthalmology·Noriyasu HashidaYasuo Tano
Dec 27, 2006·Biochemical and Biophysical Research Communications·Masahiko HiraiNoboru Yamazaki
Nov 27, 2007·Experimental Eye Research·Noriyasu HashidaYasuo Tano

❮ Previous
Next ❯

Citations

Dec 12, 2012·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kishore CholkarAshim K Mitra
Apr 11, 2009·Trends in Pharmacological Sciences·Mary K O'Reilly, James C Paulson
May 11, 2019·The Journal of Pharmacology and Experimental Therapeutics·Vrinda GoteDhananjay Pal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.