Eye manifestations of congenital toxoplasmosis

American Journal of Ophthalmology
Marilyn B MetsRima McLeod

Abstract

To determine the natural history of treated and untreated congenital toxoplasmosis and impact of this infection on vision. In this prospective, longitudinal study, 76 newborns were treated with pyrimethamine and sulfadiazine for approximately one year, and 18 individuals not treated during their first year of life entered the study after age 1 year (historical patients). Chorioretinal scars were the most common eye finding in all patients and were most common in the periphery (58% of treated and 82% of historical patients). Macular scars were present in 54% of the treated patients; 41% were bilateral. Macular scars were present in 76% of the historical patients; 23% were bilateral. Visual acuity in the presence of macular lesions ranged from 20/20 to 20/400. Of the patients followed up from the newborn period and treated, 29% had bilateral visual impairment, with visual acuity for the best eye of less than 20/40. Causes for this visual impairment in eyes with quiescent lesions included macular scars, dragging of the macula secondary to a peripheral lesion, retinal detachment, optic atrophy, cataract, amblyopia, and phthisis. There were recurrences in both treated (13%, 7/54) and previously untreated historical patients (44%, 8/...Continue Reading

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Citations

Jan 5, 2002·Ophthalmology·Lotje H Bosch-DriessenAniki Rothova
Jan 27, 2000·Ophthalmology·L H Bosch-DriessenA Rothova
May 3, 2002·Ophthalmology·Lotje E H Bosch-DriessenAniki Rothova
Mar 20, 2008·Survey of Ophthalmology·Marilyn Baird Mets, Manpreet Singh Chhabra
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Jul 17, 2010·American Journal of Obstetrics and Gynecology·Alain BerrébiJean-Marc Ayoubi
Aug 26, 2011·Parasites & Vectors·Peng ZhouXing-Quan Zhu
Aug 30, 2008·American Journal of Ophthalmology·Emmanuelle DelairAntoine P Brézin
May 12, 2009·Memórias do Instituto Oswaldo Cruz·Alessandra G CommodaroRubens Belfort
Nov 15, 2003·Current Opinion in Ophthalmology·Aniki Rothova
Mar 15, 2006·International Ophthalmology·Hassane IzzedineGilbert Deray
May 21, 2011·Ocular Immunology and Inflammation·Daniel Vitor Vasconcelos-SantosFernando Oréfice
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Apr 15, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Khadijeh KhanalihaBorna Salemi
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Jan 6, 2006·Journal français d'ophtalmologie·Z BenzinaJ Feki

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