Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment

Frontiers in Neurology
A SerraM Matta

Abstract

Multiple sclerosis (MS) commonly causes eye movement abnormalities that may have a significant impact on patients' disability. Inflammatory demyelinating lesions, especially occurring in the posterior fossa, result in a wide range of disorders, spanning from acquired pendular nystagmus (APN) to internuclear ophthalmoplegia (INO), among the most common. As the control of eye movements is well understood in terms of anatomical substrate and underlying physiological network, studying ocular motor abnormalities in MS provides a unique opportunity to gain insights into mechanisms of disease. Quantitative measurement and modeling of eye movement disorders, such as INO, may lead to a better understanding of common symptoms encountered in MS, such as Uhthoff's phenomenon and fatigue. In turn, the pathophysiology of a range of eye movement abnormalities, such as APN, has been clarified based on correlation of experimental model with lesion localization by neuroimaging in MS. Eye movement disorders have the potential of being utilized as structural and functional biomarkers of early cognitive deficit, and possibly help in assessing disease status and progression, and to serve as platform and functional outcome to test novel therapeutic a...Continue Reading

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Nov 27, 2019·Current Opinion in Neurology·Jorge C Kattah, David S Zee
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Aug 6, 2021·Continuum : Lifelong Learning in Neurology·Kamala Saha

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Methods Mentioned

BETA
imaging techniques

Clinical Trials Mentioned

NCT02391961

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