Eye-movement behavior reveals relational memory impairment in schizophrenia.

Biological Psychiatry
Lisa E WilliamsStephan Heckers

Abstract

Previous studies have demonstrated impaired relational memory in schizophrenia. We studied eye-movement behavior as an indirect measure of relational memory, together with forced-choice recognition as an explicit measure. Thirty-five patients with schizophrenia and 35 healthy participants were trained to associate a face with a background scene. During testing, scenes were presented as a cue and then overlaid with three previously studied faces. Participants were asked to recall the matching face, and both eye movements and forced-choice recognition were recorded. During Non-Match trials, no faces matched the scene. During Match trials, one of the faces had previously been paired with the scene. On Non-Match trials, when no relational memory trace was present, both groups viewed the three faces equally. In contrast, on Match trials, control participants quickly (within 500 msec) and consistently (70%-75% of test trial viewing) showed preferential viewing of the matching face. Viewing of the matching face was significantly delayed and reduced in schizophrenia participants. Forced-choice recognition of the matching face was also impaired in the patient group. An analysis of all correct Match trials revealed that preferential view...Continue Reading

References

Nov 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·R C YoungD A Meyer
Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Mar 13, 1998·Annual Review of Psychology·D L SchacterW Koutstaal
Jul 23, 1998·Neuropsychology·R W Heinrichs, K K Zakzanis
Jan 5, 2000·The American Journal of Psychiatry·I C WrightE T Bullmore
Nov 14, 2000·Neuropsychologia·B ElvevågT E Goldberg
Feb 24, 2001·Psychological Science·J D RyanN J Cohen
May 10, 2001·Schizophrenia Research·M E ShentonR W McCarley
Nov 24, 2001·Behavioural Brain Research·H Eichenbaum
Nov 27, 2002·The American Journal of Psychiatry·Raquel E GurRuben C Gur
Jun 26, 2003·The Journal of Clinical Psychiatry·Scott W Woods
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Dec 16, 2003·Cognitive, Affective & Behavioral Neuroscience·Jennifer D Ryan, Neal J Cohen
Apr 22, 2004·Schizophrenia Research·Debra TitoneDeborah L Levy
Jun 1, 2004·The American Journal of Psychiatry·J Daniel RaglandRaquel E Gur
Jul 5, 2005·Biological Psychiatry·Aaron Bonner-JacksonDeanna M Barch
Oct 8, 2005·Neuropsychology Review·Mario FioravantiLinda Clare
Apr 6, 2006·Archives of General Psychiatry·Dost OngürStephan Heckers
Jul 4, 2006·Biological Psychiatry·Martin LepageSamarthji Lal
Oct 6, 2006·Biological Psychiatry·Anthony P WeissStephan Heckers
Jul 7, 2007·Memory·Jennifer D RyanNeal J Cohen
Aug 3, 2007·International Review of Psychiatry·Benedicto Crespo-FacorroJosé Manuel Rodríguez-Sánchez
Aug 29, 2007·Psychological Bulletin·Abraham Reichenberg, Philip D Harvey
Sep 15, 2007·Journal of Cognitive Neuroscience·Deborah E HannulaNeal J Cohen
Feb 14, 2008·Nature Reviews. Neuroscience·Chris M Bird, Neil Burgess
May 23, 2008·Biological Psychiatry·Charan RanganathJ Daniel Ragland
Sep 25, 2008·British Medical Bulletin·Katie Marwick, Jeremy Hall
Oct 11, 2008·Brain and Cognition·Gillian A O'Driscoll, Brandy L Callahan
Oct 14, 2008·Brain and Cognition·G R Barnes
May 6, 2009·Neuropsychology·Raquelle I Mesholam-GatelyLarry J Seidman
Jul 23, 2009·Psychiatry Research·David LuckMartin Lepage
Jul 30, 2009·Neuropsychology Review·Victoria M Leavitt, Terry E Goldberg
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel Paul Eisenberg, Karen Faith Berman
Dec 17, 2009·Frontiers in Neuroscience·Alex Konkel, Neal J Cohen

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Citations

May 23, 2012·Neuropsychology·Kristan ArmstrongStephan Heckers
Dec 8, 2010·Schizophrenia Bulletin·Kristan ArmstrongStephan Heckers
Nov 30, 2011·Schizophrenia Bulletin·John D RaglandCameron S Carter
Nov 22, 2011·Schizophrenia Bulletin·John D RaglandCharan Ranganath
Sep 12, 2013·European Archives of Psychiatry and Clinical Neuroscience·Suzanne N AveryStephan Heckers
Nov 10, 2013·Schizophrenia Research·Lisa E WilliamsStephan Heckers
Dec 16, 2011·Trends in Cognitive Sciences·Deanna M Barch, Alan Ceaser
Nov 8, 2011·Biological Psychiatry·Lisa E WilliamsStephan Heckers
Jul 28, 2012·Bipolar Disorders·Julia M SheffieldStephan Heckers
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Deanna M Barch, Julia M Sheffield
Oct 18, 2014·Frontiers in Human Neuroscience·Rachael D RubinNeal J Cohen
Nov 19, 2013·Behavioral Sciences·Elena A SpiekerLaura M Rowland
Jul 14, 2020·Schizophrenia Bulletin·Suzanne N AveryStephan Heckers
Jul 28, 2020·Cognition·Jonathon WhitlockLili Sahakyan
Jul 24, 2021·Cerebral Cortex Communications·Bernhard FehlmannDominique J-F de Quervain

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