Eye movement disorders are different in Parkin-linked and idiopathic early-onset PD

Neurology
B MachnerW Heide

Abstract

Parkin gene mutations are the most common cause of early-onset parkinsonism. Patients with Parkin mutations may be clinically indistinguishable from patients with idiopathic early-onset Parkinson disease (EOPD) without Parkin mutations. Eye movement disorders have been shown to differentiate parkinsonian syndromes, but have never been systematically studied in Parkin mutation carriers. Eye movements were recorded in symptomatic (n = 9) and asymptomatic Parkin mutation carriers (n = 13), patients with idiopathic EOPD (n = 14), and age-matched control subjects (n = 27) during established oculomotor tasks. Both patients with EOPD and symptomatic Parkin mutation carriers showed hypometric prosaccades toward visual stimuli, as well as deficits in suppressing reflexive saccades toward unintended targets (antisaccade task). When directing gaze toward memorized target positions, patients with EOPD exhibited hypometric saccades, whereas symptomatic Parkin mutation carriers showed normal saccades. In contrast to patients with EOPD, the symptomatic Parkin mutation carriers showed impaired tracking of a moving target (reduced smooth pursuit gain). The asymptomatic Parkin mutation carriers did not differ from healthy control subjects in any...Continue Reading

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Citations

Jun 24, 2014·Journal of Ophthalmology·Martin GorgesJan Kassubek
Jun 14, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Christoph HelmchenAndreas Sprenger
Sep 16, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Björn MachnerChristoph Helmchen
Nov 25, 2017·Frontiers in Neurology·Elena Pretegiani, Lance M Optican
Mar 21, 2021·Neuropsychology Review·Josefine WaldthalerLars Timmermann
Jul 29, 2021·Clinical Parkinsonism & Related Disorders·Karen Frei

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