Eye Movements Evoked by Pulsed Infrared Radiation of the Rat Vestibular System

Annals of Biomedical Engineering
Weitao Jiang, Suhrud M Rajguru

Abstract

Light at infrared wavelengths has been demonstrated to modulate the pattern of neural signals transmitted from the angular motion sensing semicircular canals of the vestibular system to the brain. In the present study, we have characterized physiological eye movements evoked by focused, pulsed infrared radiation (IR) stimuli directed at an individual semicircular canal in a mammalian model. Pulsed IR (1863 nm) trains were directed at the posterior semicircular canal in a rat using 200-400 µm optical fibers. Evoked bilateral eye movements were measured using a custom-modified video-oculography system. The activation of vestibulo-ocular motor pathways by frequency modulated pulsed IR directed at single posterior semicircular canals evoked significant, characteristic bilateral eye movements. In this case, the resulting eye movements were disconjugate with ipsilateral eye moving upwards with a rotation towards the stimulated ear and the contralateral eye moving downwards. The eye movements were stable through several hours of repeated stimulation and could be maintained with 30 + minutes of continuous, frequency-modulated IR stimulation. Following the measurements, the distance of the fiber from target structures and orientation of...Continue Reading

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Citations

Dec 8, 2021·Neuroreport·Yi Ran WangFrançois Champoux

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Methods Mentioned

BETA
dissection
irradiating

Software Mentioned

MATLAB
Image J
Osirix
Osirix Lite

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