PMID: 9646837Jul 1, 1998Paper

Eye muscle antibodies in patients with ocular myasthenia gravis: possible mechanism for eye muscle inflammation in acetylcholine-receptor antibody-negative patients

Clinical Immunology and Immunopathology
K GunjiJ R Wall

Abstract

Myasthenia gravis is an organ-specific autoimmune disorder generally thought to be caused by an antibody-mediated attack against the skeletal muscle nicotinic acetylcholine (Ach) receptor (AchR) at the neuromuscular junction. Extraocular muscle weakness and double vision are present in about 90% of patients with myasthenia gravis and are the predominant complaints in about 20% of patients, when the condition is called ocular myasthenia gravis (OMG). While serum antibodies against the AchR are detected in most patients with generalized myasthenia gravis (GMG), they are not found in about one-third of patients with the ocular variety, and epidemiological, clinical, and serological studies suggest that OMG and GMG are two separate diseases. Both forms of myasthenia gravis are sometimes associated with thyroid autoimmunity or thyroid-associated ophthalmopathy (TAO). We have therefore tested the sera of patients with GMG and OMG by Western blotting for antibodies against porcine eye muscle membrane proteins in general, and by enzyme-linked immunosorbent assays (ELISA) specifically for reaction with two skeletal muscle antigens which are prominent marker antigens for TAO, namely, the calcium-binding protein calsequestrin and the so-c...Continue Reading

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Citations

Sep 23, 2006·The Neurologist·Linda L KusnerHenry J Kaminski
Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·B TackenbergN Sommer
Mar 3, 2001·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·J S WeizerD K Coats
Apr 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·V ZouvelouD Vassilopoulos
Jul 30, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rachel HewerBernard Rees Smith
Aug 28, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·S KawamotoE K Fishman
May 29, 2004·Journal of Endocrinological Investigation·T MizokamiJ R Wall
Jun 10, 2005·European Journal of Ophthalmology·S KloproggeA G Frauman
Aug 20, 2019·Journal of Neuromuscular Diseases·Robert H P de MeelJan J G M Verschuuren

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