Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease

American Journal of Medical Genetics
V AroltE Schwinger

Abstract

The difficulties in defining the borders of the schizophrenia spectrum is one major source of variance in linkage studies of schizophrenia. The employment of biological markers may prove advantageous. Due to empirical evidence, eye tracking dysfunction (ETD) has been discussed to be the most promising marker for genetic liability to schizophrenia. With respect to the recent progress in genomic scans, which have pointed to the short arm of chromosome 6, we carried out a scan of the 6p21-23 region with 16 microsatellite markers to test for linkage between chromosomal markers and ETD as well as schizophrenia. We tested 5 models of inheritance of ETD and found maximum two-point lod scores of 3.51 for D6S271 and 3.44 for D6S282. By including these markers in a multipoint analysis, a lod score of 4.02 was obtained. In the case of schizophrenia, 7 models were tested; however, with non-significant results. Our findings, together with another recent linkage report, point to the possibility of a second susceptibility locus for schizophrenia which may be located centromeric to the HLA region. Also, the evidence of ETD being a susceptibility marker for schizophrenia receives further support.

References

Jul 1, 1978·Archives of General Psychiatry·J Endicott, R L Spitzer
Oct 1, 1992·Journal of Psychiatric Research·P S Holzman
Oct 1, 1992·The American Journal of Psychiatry·W M GroveJ Katsanis
Oct 1, 1991·Archives of General Psychiatry·D H BlackwoodJ C Duffy
Jul 1, 1990·Psychological Bulletin·B A Clementz, J A Sweeney
Jan 1, 1989·Schizophrenia Bulletin·K S KendlerD Walsh
Jan 1, 1988·Medical & Biological Engineering & Computing·J P ReulenJ E Bos
Jan 1, 1986·Human Heredity·P McGuffin, E Sturt
Jul 13, 1973·Science·P S HolzmanD W Hughes
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M LathropJ Ott
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Nov 1, 1995·Nature Genetics·B J MowryL Sharpe
Nov 1, 1995·Nature Genetics·H GurlingJ Brynjolfsson
Nov 1, 1995·Nature Genetics·S E AntonarakisB Dombroski
Aug 1, 1994·Neuropathology and Applied Neurobiology·A G Cardno, P McGuffin
Sep 15, 1994·American Journal of Medical Genetics·M Rutter
Mar 15, 1994·American Journal of Medical Genetics·C L BarrL Giuffra
Mar 15, 1994·American Journal of Medical Genetics·H CoonM Leppert
Aug 1, 1994·Schizophrenia Research·P S Holzman
Jul 1, 1994·Human Heredity·A A SchäfferR W Cottingham
Oct 1, 1993·Archives of General Psychiatry·K S KendlerD Walsh
Jan 1, 1993·Schizophrenia Bulletin·D L LevyN R Mendell
Jan 1, 1993·Schizophrenia Bulletin·K S Kendler, S R Diehl
Jan 1, 1996·European Archives of Psychiatry and Clinical Neuroscience·V AroltE Schwinger

❮ Previous
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Citations

Mar 28, 2002·Cellular and Molecular Life Sciences : CMLS·D M WaterwortL M Brzustowicz
May 12, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Richard DelormeMarion Leboyer
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Gerard Marek, Kalpana Merchant
Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·William T Carpenter, James I Koenig
May 27, 2008·Schizophrenia Bulletin·Ping-I Lin, Braxton D Mitchell
Jun 2, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Emmanuel H DuringM J de Leon
Dec 29, 2000·The Australian and New Zealand Journal of Psychiatry·D Copolov, J Crook
May 4, 1999·Acta Psychiatrica Scandinavica. Supplementum·M T Tsuang, S V Faraone
Oct 11, 2007·Molecular Psychiatry·G KaroutzouD E Dietrich
Jul 21, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Monojit DebnathGanesan Venkatasubramanian
Jun 24, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Steven MatthysseJosef Parnas
Dec 24, 2015·Frontiers in Psychology·Nicolas CarvalhoPierre Vandel
Sep 14, 2010·Schizophrenia Research·P I Lin, A R Shuldiner
Jun 20, 2008·Neuroscience Letters·Chi-Un PaeAlessandro Serretti
May 20, 2004·Psychiatry and Clinical Neurosciences·Mohammad Z Haider, Mohammad A Zahid
Jun 25, 2003·Psychophysiology·Gunvant K ThakerHelene M Adami
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jill M GoldsteinTracey L Petryshen
Jan 18, 2005·Schizophrenia Research·Alexandra SpornJudith L Rapoport
Sep 15, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Thomas A Ban
Jan 21, 2004·Biological Psychiatry·Xingguang LuoJoel Gelernter
Dec 18, 2001·Biological Psychiatry·D R WeinbergerT E Goldberg
Feb 22, 2000·Biological Psychiatry·A E Pulver
Aug 12, 1999·American Journal of Human Genetics·S B RobertsK S Kendler
Mar 22, 2014·Biochemical Society Transactions·Masanari ItokawaToshio Miyata
Sep 12, 2007·Expert Opinion on Therapeutic Targets·Gunvant K Thaker
Jan 29, 2011·Nordic Journal of Psychiatry·H Magnus HaraldssonEngilbert Sigurdsson
May 7, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Sara A BeedieDavid M St Clair
Aug 4, 2009·Psychiatry Research·H Magnus HaraldssonHannes Petursson
Aug 6, 1999·Biological Psychiatry·W T CarpenterB Kirkpatrick
Jul 8, 1999·Biological Psychiatry·L E AdlerM C Waldo
Sep 22, 2001·Biological Psychiatry·G WintererD R Weinberger
Jul 8, 1999·Biological Psychiatry·D MalaspinaR Van Heertum
Nov 20, 1998·Tissue Antigens·A Foissac, A Cambon-Thomsen
Dec 21, 2000·Current Psychiatry Reports·G K Thaker
May 17, 2000·American Journal of Medical Genetics·M T Tsuang, S V Faraone
May 17, 2000·American Journal of Medical Genetics·M E Calkins, W G Iacono
Feb 21, 1997·American Journal of Medical Genetics·K K Kidd

❮ Previous
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