PMID: 22353686Feb 23, 2012Paper

Ezetimibe ameliorates atherosclerotic and inflammatory markers, atherogenic lipid profiles, insulin sensitivity, and liver dysfunction in Japanese patients with hypercholesterolemia

Journal of Atherosclerosis and Thrombosis
Noboru TamakiMasamitsu Nakazato

Abstract

Ezetimibe reduces serum low-density lipoprotein cholesterol (LDL-C) levels by inhibiting intestinal cholesterol absorption; however, the effects of ezetimibe, including its pleiotropic effects, have not been fully clarified. The aims of our study were to examine the efficacy of ezetimibe for hypercholesterolemia and its pleiotropic effects. Outpatients with hyper LDL-C levels were treated with 10 mg ezetimibe once a day for 12 weeks. Serum lipid profiles, atherosclerotic and inflammatory markers, glucose, insulin, liver function, and cholesterol absorption and synthesis markers were measured before and after treatment. Seventy-five patients treated with ezetimibe monotherapy and 16 patients treated with combined therapy of ezetimibe with different statins completed this study. Following 12 weeks of ezetimibe monotherapy, serum LDL-C, triglyceride, remnant-like particles cholesterol, matrix metalloproteinase-9, insulin, homeostasis model assessment of insulin resistance, high-sensitivity C-reactive protein, the relative mobility of the peak of the LDL fraction, and cholesterol absorption markers were significantly decreased, and high-density lipoprotein cholesterol and lathosterol were significantly increased. In the combined th...Continue Reading

References

Dec 2, 1999·Diabetes Research and Clinical Practice·K ShiraiY Miyashita
Oct 9, 2002·Circulation·Thomas SudhopKlaus von Bergmann
Feb 21, 2004·Science·Scott W AltmannMichael P Graziano
Mar 10, 2005·The New England Journal of Medicine·John C LaRosaUNKNOWN Treating to New Targets (TNT) Investigators
Jan 13, 2006·Current Opinion in Lipidology·Johan Sundström, Ramachandran S Vasan
May 24, 2007·Current Medical Research and Opinion·Mihalis KalogirouMoses Elisaf
Aug 23, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eric D LabontéPhilip N Howles
Mar 24, 2009·Journal of Lipid Research·André J TremblayPatrick Couture
Jun 6, 2009·European Journal of Clinical Investigation·D MasudaS Yamashita
Jul 15, 2009·Journal of Hepatology·Yuichi NozakiAtsushi Nakajima
Aug 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Mitsunori NomuraMasayuki Yoshida
Oct 14, 2009·Lipids in Health and Disease·Minako Yamaoka-TojoTohru Izumi
Jan 16, 2010·Journal of Atherosclerosis and Thrombosis·Shinya HiramitsuYukio Ozaki
Feb 13, 2010·Journal of Atherosclerosis and Thrombosis·Shusuke YagiMasataka Sata
Apr 24, 2010·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masato YonedaAtsushi Nakajima
Jun 15, 2010·Journal of Atherosclerosis and Thrombosis·José C SandovalShizuya Yamashita
Jul 24, 2010·The Journal of Pharmacology and Experimental Therapeutics·Masaya FukudaShokei Kim-Mitsuyama
Jul 27, 2010·Journal of Gastroenterology·Hyohun ParkTakeshi Okanoue
Aug 3, 2010·Metabolism: Clinical and Experimental·Tomonori MuraokaYasuo Terauchi
Oct 1, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J A DawsonM M Thompson
Feb 25, 2011·Diabetology & Metabolic Syndrome·Fernanda Bu PulziJoão E Salles

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Citations

Jun 30, 2012·Journal of Gastroenterology and Hepatology·Chun-Jen Liu
Sep 13, 2013·Journal of Atherosclerosis and Thrombosis·Mitsuyoshi TakaharaIichiro Shimomura
Jan 13, 2015·Lipids in Health and Disease·Hisashi AdachiUNKNOWN ERASE METS Study Investigators
Dec 3, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Bernard Lawrence MariniDavid G Frame
Feb 11, 2015·Metabolism: Clinical and Experimental·Makoto KuranoKazuhisa Tsukamoto
Oct 21, 2016·The American Journal of Cardiology·Peter P TothAndrew M Tershakovec
Sep 25, 2017·Cardiovascular Therapeutics·Elizandra Silva GuimarãesRosario Dominguez Crespo Hirata
Feb 11, 2014·Expert Review of Cardiovascular Therapy·Jing PangGerald F Watts
Mar 30, 2013·The Journal of Pharmacology and Experimental Therapeutics·Yoshizumi KishinoToshinori Kamisako
Jan 22, 2019·Current Vascular Pharmacology·Andromachi ReklouVasilios Athyros
Jun 20, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·Yicong YeShuyang Zhang
May 11, 2012·Journal of Cardiovascular Pharmacology and Therapeutics·George N KouvelosHaralampos J Milionis

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