Ezetimibe reduces fatty acid quantity in liver and decreased inflammatory cell infiltration and improved NASH in medaka model

Biochemical and Biophysical Research Communications
Toshiyuki OishiIsao Sakaida

Abstract

We previously developed medaka non-alcoholic steatohepatitis (NASH) model. The model showed similar histology with human NASH so we analyzed the effect of drug using medaka NASH activity score (MNAS). In this study we analyzed the effect of ezetimibe, a small intestine cholesterol transporter inhibitor, on NASH. Medaka NASH model showed steatohepatits with infiltration of D-PAS positive inflammatory cell. In this study we induced medaka NASH and compared the effect of ezetimibe on medaka NASH by HFD. As compared with the HFD group, ezetimibe reduced total cholesterol and triacyglycerol in the blood. But concerning with liver quantity of fatty acids in the liver were significantly decreased by ezetimibe. Genes related with fatty acid metabolism in liver was also decreased by ezetimibe administration. On histological observations of the liver, increases in the number of inflammatory cells and MNAS were inhibited. With this decrease of fatty acid in liver, medaka NASH was improved by ezetimibe. Ezetimibe was clarified as a useful drug to improve NASH.

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Citations

May 31, 2013·Disease Models & Mechanisms·Yoichi AsaokaHiroshi Nishina
Jan 29, 2013·Biochemical and Biophysical Research Communications·Koichiro IchimuraTomoko Obara
Jun 2, 2015·Biochimica Et Biophysica Acta·Graciela ArguelloSilvana Zanlungo
Feb 11, 2015·Atherosclerosis. Supplements·Maurizio Averna
Dec 26, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ping YeJiahong Xia
Jun 7, 2017·Scientific Reports·Koichi FujisawaIsao Sakaida

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