EZH2 promotes invasion and tumour glycolysis by regulating STAT3 and FoxO1 signalling in human OSCC cells

Journal of Cellular and Molecular Medicine
Min ZhengXin-Hua Liang

Abstract

The enhancer of zeste homolog 2 (EZH2), known as a member of the polycomb group (PcG) proteins, is an oncogene overexpressed in a variety of human cancers. Here, we found that EZH2 correlated with poor survival of oral squamous cell carcinoma (OSCC) patients using immunohistochemistry staining. EZH2 overexpression led to a significant induction in tumour glycolysis, Epithelial-mesenchymal transition (EMT), migration and invasion of OSCC cells. Conversely, silencing of EZH2 inhibited tumour glycolysis, EMT, migration and invasion in OSCC cells. Ectopic overexpression of EZH2 increased phosphorylation of STAT3 at pY705 and decreased FoxO1 expression, and FoxO1 expression was enhanced when inhibiting STAT3. In addition, EZH2 overexpression led to a significant decrease in FoxO1 mRNA levels in nude mice xenograft. These results indicated that regulation of EZH2 might have the potential to be targeted for OSCC treatment.

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Citations

Jun 5, 2020·Journal of Experimental & Clinical Cancer Research : CR·Ming-Xin CaoYa-Ling Tang
Feb 23, 2021·Cancer Science·Jinhua HuangTiejun Zhao
Jul 7, 2021·Current Pharmaceutical Design·Jinlan ChenChengfu Yuan

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Methods Mentioned

BETA
xenograft
transfection
PCR
flow cytometry
Fluorescence

Software Mentioned

GraphPad Prism
GraphPad
ImageJ

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