Ezrin--a useful factor in the prognosis of nephrotic syndrome in children: an immunohistochemical approach

Journal of Clinical Pathology
D Ostalska-NowickaM Witt

Abstract

Minimal change disease (MCD) and diffuse mesangial proliferation (DMP) are the most common pathomorphological forms of nephrotic syndrome glomerulopathies in children. The clinical course of DMP can be characterised by either DMP-sensitivity (DMP-S) or DMP-resistance (DMP-R) to steroids, resulting in an unfavourable course of the glomerulopathy. Although the clinical processes of DMP-S and DMP-R are initially identical, resistance to steroids may be foreseen by the immunohistochemical expression of cytoskeleton-associated proteins in podocytes. To estimate the immunohistochemical expression of ezrin in children with MCD, DMP and focal segmental glomerulosclerosis (FSGS) and to evaluate its usefulness in predicting resistance to steroids. Renal biopsy specimens of patients with MCD (n = 15), DMP (n = 16) and FSGS (n = 6) were taken. The control tissue consisted of normal-appearing cortex taken from kidneys resected for localised neoplasms (n = 6). The indirect immunohistochemical protocol for the use of a monoclonal antibody directed against ezrin was used. The immunohistochemical expression of ezrin in cases progressively reduced from MCD to DMP-S to DMP-R to FSGS. Except for DMP-R and FSGS (p>0.05), the difference in ezrin exp...Continue Reading

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Citations

Jan 20, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Danuta Ostalska-NowickaMartin Witt
Aug 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kar Neng LaiSydney C W Tang
Feb 24, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stefan ReuterGert Gabriëls
Apr 1, 2015·Proteomics. Clinical Applications·Dawn J CasterDavid W Powell
Jul 19, 2012·The FEBS Journal·Elizabeth Anne McRobertLeon A Bach
Sep 13, 2013·Toxicology Mechanisms and Methods·Xiuzhen FanM Firoze Khan

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