Ezrin promotes ovarian carcinoma cell invasion and its retained expression predicts poor prognosis in ovarian carcinoma

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Martin KöbelSteffen Hauptmann

Abstract

The majority of patients diagnosed with ovarian carcinoma are classified as being in advanced stage of disease. In a situation of cancer spread throughout the abdominal cavity, a successful curative treatment is difficult to achieve. Therefore, preventing binding of tumor cells to the mesothelium is crucial for patients' outcome. One important mechanism is the interaction between hyaluronic acid and the CD44 receptor with its submembrane linking complex. This consists of ezrin, radixin, and moesin and connects the CD44 receptor with the cytoskeleton. To assess the role of ezrin and moesinfor ovarian carcinoma progression, we analyzed ovarian carcinoma samples from 105 patients for expression of ezrin and moesin by immunohistochemistry and correlated these data with several clinicopathological parameters. To elucidate the functional importance of ezrin and moesin, their expression was inhibited in SKOV-3 cells by RNA interference. Ezrin and moesin were strongly expressed in 49 and 48% of ovarian carcinoma samples, respectively, and their presence correlated with reduced overall survival in univariate analysis (ezrin, p=0.0189; moesin, p=0.0351). In multivariate analysis (including FIGO stage, residual tumor, histological type, a...Continue Reading

References

Aug 8, 1998·Journal of Cutaneous Pathology·T IchikawaS Taniguchi
May 14, 1999·Trends in Cell Biology·P MangeatM Martin
May 18, 1999·Biochemical and Biophysical Research Communications·N AkisawaM A Hollingsworth
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·A GautreauM Arpin
Jan 19, 2000·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S G Silverberg
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Sayda M ElbashirThomas Tuschl
Jun 6, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroichi KobayashiShuníichiro Taniguchi
Aug 2, 2003·Gynecologic Oncology·Jarna MoilanenOlli Carpén
Sep 30, 2003·Medical Oncology·L Rodríguez-RodríguezG Zotalis
Apr 28, 2004·The American Journal of Pathology·Ie-Ming Shih, Robert J Kurman
Sep 18, 2004·Virchows Archiv : an International Journal of Pathology·Martin KöbelSteffen Hauptmann

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Citations

Jan 12, 2012·International Journal of Colorectal Disease·Fredrik JörgrenGudrun Lindmark
Jan 21, 2012·Clinical & Experimental Metastasis·Jane A CipolloneCalvin D Roskelley
Sep 20, 2008·BMC Bioinformatics·Andrey A PtitsynDouglas H Thamm
Feb 2, 2011·Leukemia & Lymphoma·Ming-Hua YangLi-Zhi Cao
Dec 6, 2011·Clinical Lung Cancer·Xiao-Qin ZhangJian-Ying Zhou
Jun 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bulent CetinUgur Coskun
Sep 7, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fan ZhangXiaoying Wu
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Iwona LugowskaKatarzyna Szamotulska
Sep 14, 2016·PloS One·Vered HorwitzReuven Reich
Mar 24, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Martin KöbelSteffen Hauptmann
Jul 8, 2015·Molecular and Cellular Biology·Haydar ÇelikAykut Üren
Apr 14, 2020·Clinical and Experimental Dental Research·Masaharu NoiHiroyuki Sugihara
Mar 25, 2017·Nature Reviews. Endocrinology·D Matthew GianferanteSharon A Savage

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