F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities

Seminars in Cancer Biology
Ammar SukariAsfar S Azmi

Abstract

Cancer cachexia is a debilitating metabolic syndrome accounting for fatigue, an impairment of normal activities, loss of muscle mass associated with body weight loss eventually leading to death in majority of patients with advanced disease. Cachexia patients undergoing skeletal muscle atrophy show consistent activation of the SCF ubiquitin ligase (F-BOX) family member Atrogin-1 (also known as MAFBx/FBXO32) alongside the activation of the muscle ring finger protein1 (MuRF1). Other lesser known F-BOX family members are also emerging as key players supporting muscle wasting pathways. Recent work highlights a spectrum of different cancer signaling mechanisms impacting F-BOX family members that feed forward muscle atrophy related genes during cachexia. These novel players provide unique opportunities to block cachexia induced skeletal muscle atrophy by therapeutically targeting the SCF protein ligases. Conversely, strategies that induce the production of proteins may be helpful to counter the effects of these F-BOX proteins. Through this review, we bring forward some novel targets that promote atrogin-1 signaling in cachexia and muscle wasting and highlight newer therapeutic opportunities that can help in the better management of pa...Continue Reading

References

Jan 13, 1997·Biochemical and Biophysical Research Communications·M LloveraJ M Argilés
Jul 1, 1997·The Journal of Clinical Investigation·N E TawaA L Goldberg
Dec 3, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A R WillemsM Tyers
Dec 28, 1999·Annual Review of Cell and Developmental Biology·R J Deshaies
Mar 29, 2000·Biochemical and Biophysical Research Communications·D FischerP O Hasselgren
Feb 13, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S R PriceW E Mitch
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·M D GomesA L Goldberg
Jan 17, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gail PennerPer-Olof Hasselgren
Apr 19, 2002·Nature·Ning ZhengNikola P Pavletich
May 15, 2002·The Biochemical Journal·Dipak P Ramji, Pelagia Foka
Dec 2, 2004·Molecular and Cellular Biology·Brooke C HarrisonTimothy A McKinsey
May 21, 2005·The International Journal of Biochemistry & Cell Biology·Didier AttaixJean Grizard
Sep 22, 2005·Physiology·Michael J Tisdale
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Eric J DuellElizabeth A Holly
Nov 30, 2006·Journal of Cellular Biochemistry·Bingwen Jin, Yi-Ping Li
Apr 28, 2007·Cell Death and Differentiation·W P CawthornJ K Sethi
Sep 26, 2008·Inflammopharmacology·Q P DouT H Chan
Dec 17, 2008·Current Opinion in Supportive and Palliative Care·Didier AttaixDaniel Taillandier
Dec 17, 2008·Current Opinion in Supportive and Palliative Care·Giovanni Mantovani, Clelia Madeddu
Feb 7, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·José M Garcia, William J Polvino
Mar 6, 2009·The Journal of Medical Investigation : JMI·Dalia Ismaeil Ibrahim HemdanTakeshi Nikawa
Apr 9, 2009·Nature Reviews. Molecular Cell Biology·Brenda A Schulman, J Wade Harper
Apr 28, 2009·The British Journal of Nutrition·Rafat A SiddiquiStephen DeMichele
Oct 24, 2009·Nature Reviews. Molecular Cell Biology·Yihong Ye, Michael Rape
Dec 4, 2009·The Journal of Biological Chemistry·Rosa Viñas-CastellsVíctor M Díaz
Jul 2, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kenneth C H Fearon, Vickie E Baracos
Jul 6, 2010·Biochemical and Biophysical Research Communications·Tsuyoshi ShutoHirofumi Kai
Oct 1, 2010·Current Opinion in Supportive and Palliative Care·Jane B Hopkinson
Oct 30, 2010·Biochimica Et Biophysica Acta·Yuh Min Chook, Katherine E Süel
Feb 26, 2011·Journal of Evidence-based Medicine·Katja Boehm
Sep 20, 2011·The Journal of Biological Chemistry·Shogo WadaTakayuki Akimoto
Feb 2, 2012·Anti-cancer Agents in Medicinal Chemistry·Min ShenQ Ping Dou

❮ Previous
Next ❯

Citations

Sep 7, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gui-Yang JiangYong Zhang
Sep 16, 2017·European Journal of Preventive Cardiology·Louise G Shewan
Nov 12, 2020·Nature Reviews. Clinical Oncology·Asfar S AzmiRamzi M Mohammad
Jan 5, 2021·Frontiers in Pharmacology·Hong ZhangCheng Guo
Jan 20, 2021·Cell Death and Differentiation·Nadia HabelRobert Ballotti
Feb 9, 2021·Experimental Biology and Medicine·Chenyuan LiShengrong Sun
Nov 14, 2020·International Journal of Molecular Sciences·Kenneth C EhrlichMelanie Ehrlich
Apr 21, 2021·Phytotherapy Research : PTR·Hong ZhangCheng Guo
May 11, 2021·The Biochemical Journal·Yonghua LiZhengzhi Zou
Jul 16, 2021·Drug Discovery Today·Abdul Q KhanMartin Steinhoff
Aug 28, 2021·Life·Julia Windi GunadiRonny Lesmana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cancer Metabolism: Therapeutic Targets

Targeting the mechanisms by which cancer cells acquire energy for metabolic needs is a therapeutic target. Discover the latest research on cancer metabolism and therapeutic targets.