F0F1 ATP synthase activity is differently modulated by coronary reactive hyperemia before and after ischemic preconditioning in the goat

American Journal of Physiology. Heart and Circulatory Physiology
Claudia PennaIrene Mavelli

Abstract

The amplitude of coronary reactive hyperemia (CRH), elicited by 15 s of ischemia, is reduced in hearts subjected to 5 min of ischemic preconditioning (IP). F0F1 ATP synthase activity and ATP concentration are also altered by IP. We hypothesized that F0F1 ATP synthase is differently modulated by the inhibitor protein IF(1) during CRH elicited before (CRHnp) and after (CRHprec) IP. Hemodynamic parameters were recorded in 10 anesthetized goats. Myocardial biopsies were obtained before IP (Cnp), during CRHnp, 4 and 6 min after the onset of CRHnp, after IP (Cprec), during CRHprec, and 4 min after CRHprec. F0F1 ATP synthase activity, ATP concentration, and ATP-to-ADP ratio (ATP/ADP) were determined. Compared with CRHnp, IP blunted CRHprec. F0F1 ATP synthase activity transiently increased during CRHnp, decreased 4 min after CRHnp, and returned to control 2 min later; it was lower after IP (Cprec) and did not change during and after CRHprec. All these changes in activity were modulated by IF1. During CRHnp, ATP concentration and ATP/ADP were reduced compared with Cnp and began to rise 6 min thereafter. During Cprec, both parameters were transiently reduced but increased during and after CRHprec. Hence, during CRHnp, F0F1 ATP synthase a...Continue Reading

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Citations

Jul 24, 2010·Antioxidants & Redox Signaling·Pasquale PagliaroClaudia Penna
Jun 29, 2010·Antioxidants & Redox Signaling·Kerstin BoenglerRainer Schulz
Oct 26, 2013·Basic Research in Cardiology·Francesca TullioPasquale Pagliaro
Dec 2, 2014·Atherosclerosis·Laurent O MartinezLaeticia Lichtenstein
Oct 11, 2014·British Journal of Pharmacology·P Pagliaro, C Penna
Mar 3, 2009·Biochimica Et Biophysica Acta·Claudia PennaPasquale Pagliaro
Sep 14, 2007·Journal of Bioenergetics and Biomembranes·Stefania ContessiIrene Mavelli
Apr 24, 2009·Journal of Bioenergetics and Biomembranes·Giovanna LippeIrene Mavelli
Feb 9, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Marina ComelliIrene Mavelli
Mar 29, 2014·Experimental Biology and Medicine·Claudia PennaPasquale Pagliaro

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