F1F0-ATP synthases of alkaliphilic bacteria: lessons from their adaptations

Biochimica Et Biophysica Acta
D B HicksT A Krulwich

Abstract

This review focuses on the ATP synthases of alkaliphilic bacteria and, in particular, those that successfully overcome the bioenergetic challenges of achieving robust H+-coupled ATP synthesis at external pH values>10. At such pH values the protonmotive force, which is posited to provide the energetic driving force for ATP synthesis, is too low to account for the ATP synthesis observed. The protonmotive force is lowered at a very high pH by the need to maintain a cytoplasmic pH well below the pH outside, which results in an energetically adverse pH gradient. Several anticipated solutions to this bioenergetic conundrum have been ruled out. Although the transmembrane sodium motive force is high under alkaline conditions, respiratory alkaliphilic bacteria do not use Na+- instead of H+-coupled ATP synthases. Nor do they offset the adverse pH gradient with a compensatory increase in the transmembrane electrical potential component of the protonmotive force. Moreover, studies of ATP synthase rotors indicate that alkaliphiles cannot fully resolve the energetic problem by using an ATP synthase with a large number of c-subunits in the synthase rotor ring. Increased attention now focuses on delocalized gradients near the membrane surface ...Continue Reading

References

Apr 1, 1976·European Journal of Biochemistry·E PadanH Rottenberg
Sep 21, 1978·Biochimica Et Biophysica Acta·R J Williams
Sep 1, 1992·European Journal of Biochemistry·V P Skulachev
Jan 1, 1992·Bioscience, Biotechnology, and Biochemistry·R AonoK Horikoshi
Mar 14, 1991·European Journal of Biochemistry·A Hoffmann, P Dimroth
Apr 1, 1991·Applied and Environmental Microbiology·W A Belli, R E Marquis
Dec 12, 1990·European Journal of Biochemistry·A Hoffmann, P Dimroth
Jun 19, 1989·FEBS Letters·V P Skulachev
Jun 1, 1985·The Biochemical Journal·G FalkJ E Walker
Oct 15, 1987·European Journal of Biochemistry·W Laubinger, P Dimroth
May 7, 1986·Journal of Theoretical Biology·A L Koch
Aug 3, 1987·European Journal of Biochemistry·E C Slater
Jan 1, 1987·The Journal of Membrane Biology·E Padan, S Schuldiner
Jan 1, 1986·Methods in Enzymology·E Padan, S Schuldiner
Jan 1, 1985·Annual Review of Microbiology·O Ciferri, O Tiboni
Sep 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·S R Caplan, A Essig
Aug 1, 1966·Biological Reviews of the Cambridge Philosophical Society·P Mitchell
Jan 2, 1984·FEBS Letters·H V WesterhoffD B Kell
Apr 1, 1984·Journal of Bacteriology·D ZilbersteinE Padan
Dec 1, 1983·Microbiological Reviews·O Ciferri
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J L SlonczewskiR M Macnab
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·T M DuncanR L Cross
May 10, 1995·Biochimica Et Biophysica Acta·D B Hicks, T A Krulwich

Citations

Apr 6, 2011·Nature Reviews. Microbiology·T A KrulwichE Padan
Apr 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Laura PreissThomas Meier
Aug 7, 2010·PLoS Biology·Laura PreissThomas Meier
Apr 9, 2011·Standards in Genomic Sciences·Gerard MuyzerNikos C Kyrpides
Jan 19, 2016·Applied Microbiology and Biotechnology·Kusum Dhakar, Anita Pandey
Nov 12, 2014·Biotechnology and Bioengineering·Sunil Nath, John Villadsen
Oct 18, 2015·FEMS Microbiology Reviews·Mark DopsonTom H J A Sleutels
Apr 14, 2015·Journal of Hazardous Materials·Talitha C SantiniLesley A Warren
Oct 15, 2013·FEMS Microbiology Reviews·Florian Mayer, Volker Müller
Sep 30, 2016·Environmental Science & Technology·Talitha C SantiniLesley A Warren
Nov 1, 2016·The Journal of Antimicrobial Chemotherapy·Moloko C CholoRonald Anderson
Feb 24, 2018·Pathogens·Iram Khan IqbalAshwani Kumar
Oct 30, 2019·Journal of Molecular Evolution·Antoine Danchin, Pablo Iván Nikel
Sep 26, 2017·Standards in Genomic Sciences·Emily Denise MeltonGerard Muyzer
Feb 22, 2020·Frontiers in Plant Science·Geoffry A Davis, David M Kramer
Feb 23, 2017·Frontiers in Microbiology·Kaitlin R RempfertAlexis S Templeton
Nov 28, 2019·World Journal of Microbiology & Biotechnology·Jing GuoNing Xu
Mar 2, 2021·Environmental Science & Technology·Talitha C SantiniMaija J Raudsepp

Related Concepts

Related Feeds

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.