F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus

Endocrinology
Mahiro EgashiraYutaka Osuga

Abstract

Cellular senescence, defined as an irreversible cell cycle arrest, exacerbates the tissue microenvironment. Our previous study demonstrated that mouse uterine senescent cells were physiologically increased according to gestational days and that their abnormal accumulation was linked to the onset of preterm delivery. We hypothesized that there is a mechanism for removal of senescent cells after parturition to maintain uterine function. In the current study, we noted abundant uterine senescent cells and their gradual disappearance in wild-type postpartum mice. F4/80+ macrophages were present specifically around the area rich in senescent cells. Depletion of macrophages in the postpartum mice using anti-F4/80 antibody enlarged the area of senescent cells in the uterus. We also found excessive uterine senescent cells and decreased second pregnancy success rate in a preterm birth model using uterine p53-deleted mice. Furthermore, a decrease in F4/80+ cells and an increase in CD11b+ cells with a senescence-associated inflammatory microenvironment were observed in the p53-deleted uterus, suggesting that uterine p53 deficiency affects distribution of the macrophage subpopulation, interferes with senescence clearance, and promotes senes...Continue Reading

References

Jul 1, 1969·Journal of Reproduction and Fertility·A S Bingel, N B Schwartz
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Apr 26, 2003·Journal of Leukocyte Biology·Luisa Martinez-PomaresSimon Y C Wong
Aug 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sheena A LinehanSiamon Gordon
Mar 1, 1965·Experimental Cell Research·L HAYFLICK
Feb 1, 2005·Genesis : the Journal of Genetics and Development·Selma M SoyalJohn P Lydon
Apr 22, 2006·Aging Cell·Bo Yun LeeEun Seong Hwang
Aug 2, 2007·Nature Reviews. Molecular Cell Biology·Judith Campisi, Fabrizio d'Adda di Fagagna
Jan 18, 2008·Developmental Biology·Gracy X RosarioMichael J Soares
Aug 30, 2008·Cell·Valery KrizhanovskyScott W Lowe
Feb 17, 2009·Fertility and Sterility·Erika B Johnston-MacAnannyClaudio A Benadiva
Nov 13, 2009·The Journal of Clinical Investigation·Denis BedoretFabrice Bureau
Dec 24, 2009·Nature Reviews. Cancer·Manuel Collado, Manuel Serrano
Feb 4, 2010·The Journal of Clinical Investigation·Yasushi HirotaSudhansu K Dey
Apr 14, 2010·Particle and Fibre Toxicology·Elizabeth A RondiniAlison K Bauer
Nov 17, 2010·Genes & Development·Thomas KuilmanDaniel S Peeper
Oct 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Yasushi HirotaSudhansu K Dey
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Apr 9, 2013·Cell·Amaia LujambioScott W Lowe
Jul 23, 2013·Nature Neuroscience·Veronique E MironCharles Ffrench-Constant
Aug 28, 2013·The Journal of Clinical Investigation·Jeeyeon ChaYasushi Hirota
Nov 19, 2013·Cell·Daniel Muñoz-EspínManuel Serrano
May 16, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Si Eun HwangBaik Hwan Cho
May 23, 2014·Molecular Endocrinology·Hirofumi HaraguchiYutaka Osuga
Jul 2, 2015·Seminars in Reproductive Medicine·Alin L AkopiansErica T Wang
Jun 22, 2016·Placenta·Elizabeth A BonneyRamkumar Menon
Jul 28, 2016·The Journal of Clinical Investigation·Wenbo DengSudhansu K Dey
Dec 21, 2017·Reproductive Medicine and Biology·Ryo MaekawaNorihiro Sugino

❮ Previous
Next ❯

Citations

Apr 6, 2018·Cellular & Molecular Immunology·Xiangxiang JiangHongmei Wang
Feb 2, 2018·Journal of Leukocyte Biology·Antonietta SantoroElena Ciaglia
Aug 6, 2018·Journal of Cellular Physiology·Wenqiang Wei, Shaoping Ji
Sep 28, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hirofumi HaraguchiYutaka Osuga
Jan 3, 2018·The Journal of Clinical Investigation·Joon-Il Jun, Lester F Lau
Apr 20, 2019·Journal of the American Society of Nephrology : JASN·Marie-Helena DochertyDavid A Ferenbach
Jul 31, 2019·International Journal of Molecular Sciences·Andrea Olmos-OrtizVerónica Zaga-Clavellina
Dec 11, 2019·Scientific Reports·Anatoly L Mayburd, Ancha Baranova
Jun 24, 2020·International Journal of Molecular Sciences·Anthony M BattramBeatriz Martín-Antonio
Jun 11, 2020·Immunity & Ageing : I & a·Abhijit KaleJudith Campisi
Dec 23, 2020·Open Biology·Sonia S Elder, Elaine Emmerson
Jan 14, 2021·Cellular and Molecular Life Sciences : CMLS·Camilla S A Davan-WettonTrinidad Montero-Melendez
Dec 24, 2020·The Journal of Cell Biology·Jacques Behmoaras, Jesús Gil
Jun 20, 2021·Journal of Cellular and Molecular Medicine·Yanqin LiuHai-Yan Lin
Jun 29, 2021·Frontiers in Immunology·Tom O J CockramGuy C Brown
Jul 6, 2021·Frontiers in Immunology·Ross A CampbellKatie J Mylonas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.