FA-PEG decorated MOF nanoparticles as a targeted drug delivery system for controlled release of an autophagy inhibitor

Biomaterials Science
Zheqi ShiWenjun Fang

Abstract

A zeolitic imidazolate framework (ZIF-8) with high loading capacity and pH-responsive properties, an important subclass of metal-organic frameworks (MOFs), has become a promising material for drug delivery. A multifunctional drug delivery system (DDS) was designed in this work for effective targeting delivery of chloroquine diphosphate (CQ) as an autophagy inhibitor. The ZIF-8 nanoparticles encapsulating CQ (CQ@ZIF-8 NPs) were fabricated by a simple one-pot method and were then decorated with methoxy poly(ethylene glycol)-folate (FA-PEG), a special identifier of cancer cells, to form FA-PEG/CQ@ZIF-8. The target identification of FA-PEG/CQ@ZIF-8 NPs, compared with CQ@ZIF-8 NPs, leads to an increasing number of NPs being internalized into HeLa cells, which decreases the loss of drugs and results in high cytotoxicity of CQ for cancer cells. The lower viabilities of HeLa cells (cancer cells) and higher viabilities of HEK293 cells (healthy cells) treated with FA-PEG/CQ@ZIF-8 NPs show that the special target for cancer cells results from the combinations of folic acid and folate receptors on the surface of HeLa cells. The quantitative measurements of autophagy-related proteins and the detection of autophagy flux in HeLa cells suggest...Continue Reading

References

Jun 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kyo Sung ParkOmar M Yaghi
Feb 22, 2008·Current Medicinal Chemistry·A Petrelli, S Giordano
Jun 6, 2009·Journal of the American Chemical Society·Jihyun AnNathaniel L Rosi
Aug 25, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Michael C McCarthyHae-Kwon Jeong
Dec 8, 2010·Journal of the American Chemical Society·Surendar R VennaMoises A Carreon
May 15, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Chun-Yi SunEn-Bo Wang
Jul 28, 2012·ACS Applied Materials & Interfaces·Nuria LiédanaJoaquín Coronas
Jan 5, 2013·Cancer Research·Tomonori KimuraYoshitaka Isaka
Feb 6, 2013·Inorganic Chemistry·Barry A BlightSuning Wang
Aug 15, 2013·Pharmacological Reviews·Yan ChengJin-Ming Yang
May 16, 2014·Cancer Discovery·Jean M Mulcahy LevyAndrew Thorburn
Aug 25, 2015·Journal of Diabetes and Its Complications·Ying XuQiang Wan
Sep 12, 2015·Chemical Communications : Chem Comm·Stefan WuttkeThomas Bein
Apr 15, 2017·International Journal of Nanomedicine·Tan YangGuangya Xiang
Dec 2, 2017·The Journal of Biological Chemistry·Andrew Thorburn

❮ Previous
Next ❯

Citations

May 14, 2020·Advanced Healthcare Materials·Shuangqian YanBi-Feng Liu
Mar 19, 2019·Journal of Biomaterials Applications·Chong ChengYi Lv
Sep 29, 2019·Biomolecules·Shima TavakolAlan Prem Kumar
May 18, 2021·Journal of Inorganic and Organometallic Polymers and Materials·Pierre D Harvey, Jessica Plé
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Meizhe YuXiaodong Xing
Jul 29, 2021·Journal of Drug Targeting·Yingying LiGuangxi Zhai

❮ Previous
Next ❯

Methods Mentioned

BETA
scanning
transmission
X-ray
dynamic light scattering
protein assay
transfection
electrophoresis
confocal microscopy

Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.