FABP4 in Gestational Diabetes-Association between Mothers and Offspring

Journal of Clinical Medicine
Jolanta Patro-MałyszaBożena Leszczyńska-Gorzelak

Abstract

Fetuses exposed to gestational diabetes mellitus (GDM) have a higher risk of abnormal glucose homeostasis in later life. The molecular mechanisms of this phenomenon are still not fully understood. Fatty acid binding protein 4 (FABP4) appears to be one of the most probable candidates involved in the pathophysiology of GDM. The main aim of the study was to investigate whether umbilical cord serum FABP4 concentrations are altered in term neonates born to GDM mothers. Two groups of subjects were selected-28 healthy controls and 26 patients with GDM. FABP4, leptin, and ghrelin concentrations in the umbilical cord serum, maternal serum, and maternal urine were determined via an enzyme-linked immunosorbent assay. The umbilical cord serum FABP4 levels were higher in the GDM offspring and were directly associated with the maternal serum FABP4 and leptin levels, as well as the prepregnancy body mass index (BMI) and the BMI at and after delivery; however, they correlated negatively with birth weight and lipid parameters. In the multiple linear regression models, the umbilical cord serum FABP4 concentrations depended positively on the maternal serum FABP4 and negatively on the umbilical cord serum ghrelin levels and the high-density lipopr...Continue Reading

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Citations

Jun 5, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Heqin YangHaijun Gao
Sep 26, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Xiujuan Dong, Long Yang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
Statistical Package for the Social Sciences

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