Fabrication and characterisation of 3D printed MWCNT composite porous scaffolds for bone regeneration

Materials Science & Engineering. C, Materials for Biological Applications
Boyang HuangPaulo Bártolo

Abstract

Carbon nanotubes (CNTs) with exceptional physical and chemical properties are attracting significant interest in the field of tissue engineering. Several reports investigated CNTs biocompatibility and their impact in terms of cell attachment, proliferation and differentiation mainly using polymer/CNTs membranes. However, these 2D membranes are not able to emulate the complex in vivo environment. In this paper, additive manufacturing (3D printing) is used to create composite 3D porous scaffolds containing different loadings of multi-walled carbon nanotubes (MWCNT) (0.25, 0.75 and 3 wt%) for bone tissue regeneration. Pre-processed and processed materials were extensively characterised in terms of printability, morphological and topographic characteristics and thermal, mechanical and biological properties. Scaffolds with pore sizes ranging between 366 μm and 397 μm were successfully produced and able to sustain early-stage human adipose-derived mesenchymal stem cells attachment and proliferation. Results show that MWCNTs enhances protein adsorption, mechanical and biological properties. Composite scaffolds, particularly the 3 wt% loading of MWCNTs, seem to be good candidates for bone tissue regeneration.

Citations

Sep 10, 2020·International Journal of Molecular Sciences·Gangadhar LekshmiWanxi Peng
Jul 18, 2019·Materials·Guilherme CaetanoMarco Andrey Cipriani Frade
Feb 9, 2020·Nanomaterials·Kaoru Aoki, Naoto Saito
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Cian VyasPaulo Bartolo
Feb 8, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Noah Z LairdAliasger K Salem
Nov 3, 2020·3D Printing and Additive Manufacturing·Yanhao HouPaulo Bártolo
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Qifan WangQiong Rong
Sep 30, 2021·ACS Biomaterials Science & Engineering·Haoyang LiuWei Zhang
Oct 2, 2021·Advanced Materials·Hossein RavanbakhshYu Shrike Zhang

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