Fabrication and Characterization of a Magnetic Drilling Actuator for Navigation in a Three-dimensional Phantom Vascular Network

Scientific Reports
Sunkey LeeHongsoo Choi

Abstract

Intravascular microrobots have emerged as a promising tool for vascular diseases. They can be wirelessly and precisely manipulated with a high degree of freedom. Previous studies have evaluated their drilling performance and locomotion, and showed the feasibility of using microrobots for biomedical applications in two-dimensional space. However, it is critical to validate micro-drillers in a three-dimensional (3D) environment because gravity plays an important role in a 3D environment and significantly affects the performance of the micro-drillers in vascular networks. In this work, we fabricated magnetic drilling actuators (MDAs) and characterized their locomotion and drilling performance in vascular network-mimicking fluidic channels. The MDAs were precisely manipulated in the fluidic channel network in both horizontal and vertical planes, selecting and moving through the desired path via the junctions of multiple channels. The MDAs also accurately navigated an artificial thrombosis in an artificial 3D vascular network and successfully drilled through it. The results obtained here confirmed the precise manipulation and drilling performance of the developed MDAs in 3D. We think that the MDAs presented in this paper have great ...Continue Reading

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Citations

Oct 10, 2019·Advanced Healthcare Materials·Ki-Won GyakDong-Pyo Kim
Nov 14, 2019·Advanced Materials·Jun Kyu ParkJohn A Rogers
Jan 21, 2021·Chemical Society Reviews·Jinhua Li, Martin Pumera
Dec 11, 2020·Materials Today. Bio·M KoleosoX Chen
Apr 1, 2021·Chemical Reviews·Huaijuan ZhouMartin Pumera
Jun 11, 2021·Scientific Reports·Sangyeun ParkHongyun So
Oct 3, 2021·Biomedical Microdevices·Yuwen GaoLigang Yao

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Methods Mentioned

BETA
percutaneous transluminal angioplasty
MDAs
MDA
fluorescence
X-ray

Software Mentioned

In Vivo Imaging System ( IVIS )
Fiji
Solidworks
ImageJ

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