Fabrication and characterization of complex nanoparticles based on carboxymethyl short chain amylose and chitosan by ionic gelation

Food & Function
Na JiCaiming Li


We aimed to investigate whether the combination of the modification of short chain amylose (SCA) with chitosan (CS) through the electrostatic interaction could be considered as a candidate for oral delivery of bioactive ingredients. Carboxymethyl short chain amylose (CMSCA) was synthesized by reacting SCA with monochloroacetic acid. The changes in SCA levels after the reaction were investigated by zeta-potential determination, Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry, thermogravimetry and derivative thermogravimetry. Complex nanoparticles (NPs) were then synthesized using CMSCA and CS by ionic gelation. FTIR spectral analysis revealed that the complex NPs were synthesized by hydrogen bonding and electrostatic interactions between CMSCA and CS. CMSCA/CS NPs show an insulin encapsulation efficiency of 85.2% and exhibit sustained release of insulin in vitro. CMSCA/CS NPs were observed to show excellent cytocompatibility by cell culture. These findings demonstrated that CMSCA/CS NPs constructed by the ionic gelation method could be further exploited as a potential oral delivery system for peptide drugs.


Dec 14, 2002·International Journal of Pharmaceutics·Yongmei Xu, Yumin Du
Sep 15, 2012·International Journal of Biological Macromolecules·Alessandro F MartinsEdvani C Muniz
Nov 20, 2012·Advanced Drug Delivery Reviews·Mei-Chin ChenHsing-Wen Sung
Apr 9, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Maria Mihaela FriciuMircea Alexandru Mateescu
Feb 4, 2014·Journal of Agricultural and Food Chemistry·Kang PanQixin Zhong
Jun 26, 2014·Expert Opinion on Drug Delivery·Xiuying LiMingshi Yang
Dec 3, 2014·Ultrasonics Sonochemistry·Shabbar AbbasXiaoming Zhang
Jan 7, 2015·International Journal of Biological Macromolecules·Deepika VashishtK Jayaram Kumar
Mar 26, 2015·International Journal of Biological Macromolecules·D DasK Jayaram Kumar
Mar 31, 2015·Biomaterials·Kyuri KimHaeshin Lee
Feb 20, 2016·International Journal of Biological Macromolecules·Mohd Abul KalamAws Alshamsan
Feb 26, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mona AlibolandiFarzin Hadizadeh
Apr 14, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Marlene LopesHélder A Santos
Apr 16, 2016·Advanced Drug Delivery Reviews·Zhigao NiuMaría J Alonso
May 15, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jianyong ShengVictor C Yang
May 20, 2016·Drug Discovery Today·Miaorong YuYong Gan
Aug 6, 2016·Colloids and Surfaces. B, Biointerfaces·Diana SilvaBenilde Saramago
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Lei LiJuming Yao
Sep 20, 2017·Journal of Agricultural and Food Chemistry·Na JiCaiming Li
Mar 21, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yen-Jye ShyongFeng-Huei Lin

❮ Previous
Next ❯


Sep 3, 2020·Journal of Drug Targeting·Chun Y WongCrispin R Dass
Oct 31, 2020·Polymers·Francivandi Coelho BarbosaMarcus Vinícius Lia Fook
May 19, 2021·International Journal of Biological Macromolecules·Linqi YunJianbin Li
Jul 27, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hoa Phuong TranSu-Geun Yang

❮ Previous
Next ❯

Methods Mentioned

dynamic light scattering
infrared spectroscopy

Software Mentioned

Digital NanoScope Analysis

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.