Fabrication and characterization of Eri silk fibers-based sponges for biomedical application

Acta Biomaterialia
S S SilvaRui L Reis

Abstract

Cocoon-derived semi-domesticated Eri silk fibers still lack exploitation for tissue engineering applications due to their poor solubility using conventional methods. The present work explores the ability to process cocoon fibers of non-mulberry Eri silk (Samia/Philosamia ricini) into sponges through a green approach using ionic liquid (IL)--1-buthyl-imidazolium acetate as a solvent. The formation of β-sheet structures during Eri silk/IL gelation was acquired by exposing the Eri silk/IL gels to a saturated atmosphere composed of two different solvents: (i) isopropanol/ethanol (physical stabilization) and (ii) genipin, a natural crosslinker, dissolved in ethanol (chemical crosslinking). The sponges were then obtained by freeze-drying. This approach promotes the formation of both stable and ordered non-crosslinked Eri silk fibroin matrices. Moreover, genipin-crosslinked silk fibroin sponges presenting high height recovery capacity after compression, high swelling degree and suitable mechanical properties for tissue engineering applications were produced. The incorporation of a model drug--ibuprofen--and the corresponding release study from the loaded sponges demonstrated the potential of using these matrices as effective drug deli...Continue Reading

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Citations

Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marek KaweckiAleksandra Kasperczyk
Jun 30, 2018·Advanced Materials·Zhitao ZhouTiger H Tao
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kelvin O MosetiYasumoto Nakazawa
Oct 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kelvin O MosetiYasumoto Nakazawa
Dec 10, 2018·ACS Biomaterials Science & Engineering·Xiaoting ZhengYaopeng Zhang
Jan 19, 2021·ACS Biomaterials Science & Engineering·Zhinan MaoSujun Wu
Aug 13, 2018·ACS Biomaterials Science & Engineering·Gu ChengQun Wang

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