Fabrication and characterization of novel nano- and micro-HA/PCL composite scaffolds using a modified rapid prototyping process

Journal of Biomedical Materials Research. Part a
Su-Jin HeoJung-Woog Shin

Abstract

Novel three-dimensional scaffolds consisting of nano- and microsized hydroxyapatite (HA)/poly(epsilon-caprolactone) (PCL) composite were fabricated using a modified rapid-prototyping (RP) technique for bone tissue engineering applications. The size of the nano-HA ranged from 20 to 90 nm, whereas that of the micro-HA ranged from 20 to 80 microm. The scaffold macropores were well interconnected, with a porosity of 72-73% and a pore size of 500 microm. The compressive modulus of the nano-HA/PCL and micro-HA/PCL scaffolds was 3.187 +/- 0.06 and 1.345 +/- 0.05 MPa, respectively. The higher modulus of the nano-HA/PCL composite (n-HPC) was to be likely caused by a dispersion strengthening effect. The attachment and proliferation of MG-63 cells on n-HPC were better than that on the micro-HA/PCL composite (m-HPC) scaffold. The n-HPC was more hydrophilic than the m-HPC because of the greater surface area of HA exposed to the scaffold surface. This may give rise to better cell attachment and proliferation. Bioactive n-HA/PCL composite scaffold prepared using a modified RP technique has a potential application in bone tissue engineering.

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Citations

Jan 24, 2013·Critical Reviews in Biomedical Engineering·Ami R AminiSyam P Nukavarapu
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Oct 14, 2009·Biotechnology Progress·Joshua R PorterKetul C Popat
Jul 30, 2011·Journal of Biomedical Materials Research. Part a·T JensenK Søballe
Jun 25, 2010·Journal of Biomedical Materials Research. Part a·Parvin ShokrollahiWilhelm T S Huck
Aug 19, 2016·ACS Applied Materials & Interfaces·Gráinne M CunniffeFergal J O'Brien
Sep 26, 2020·Frontiers in Bioengineering and Biotechnology·Joseph G LyonsSilvia Minardi
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Maria Laura GattoPaolo Mengucci
Oct 16, 2018··Sanjay Kumar, Sanjay Kumar

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