Fabrication and characterization of poly(D,L-lactide-co-glycolide)/hydroxyapatite nanocomposite scaffolds for bone tissue regeneration

Journal of Biomedical Materials Research. Part a
Neda AboudzadehMehdi Farokhi

Abstract

Conventional methods in fabrication of scaffolds based on polymer/bioceramic composites frequently make use of solution casting then particle leaching. The residues of common organic solvents can get trapped in this technique hence provide safety concerns on final scaffold. In this study, N-methyl pyrrolidone was used as an approved solvent for parenteral pharmaceutical products especially implants with acceptable toxicological profile. A combined freeze drying and solvent casting methods were adopted for complete removal of the solvent from final scaffold structure. Biodegradable scaffolds based on poly (D,L-lactide-co-glycolide) and different percentages of nanohydroxyapatite (25, 35, and, 45% w/w) were characterized thoroughly regarding porosity, pore distribution as well as their bioactivity and biocompatibility. The results showed 70-80% porosity with a size distribution in the range of 50-200 mum for different conditions. Bioactivity of the scaffolds was directly dependent on the bioceramic content in the samples according to the results. Composites and neat samples showed the same cytocompatibility profile. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010.

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Citations

Apr 9, 2013·Nanomedicine·Nanda Gopal SahooChao Bin He
Aug 12, 2015·Journal of Functional Biomaterials·Sergey V Dorozhkin
Nov 26, 2010·Journal of Biomedical Materials Research. Part a·Ralf SmeetsAndreas Kolk
Feb 21, 2014·The Journal of Oral Implantology·Gabriel Castillo-DaliDaniel Torres-Lagares
Mar 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fatemeh MottaghitalabHossein Hosseinkhani
Nov 13, 2012·Acta Biomaterialia·Anandkumar NandakumarPamela Habibovic
Dec 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gabriele CeccarelliRuggero Rodriguez Y Baena
Nov 17, 2017·Restorative Dentistry & Endodontics·Myung-Jin LimKyung-San Min
Jan 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chandhi S GoonasekeraLisbeth Grøndahl
Oct 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Haisheng PengQun Wang
Oct 28, 2013·Biomaterials Science·Changchun ZhouXingdong Zhang
Mar 7, 2021·Annals of Biomedical Engineering·Bharti BishtManash K Paul
Aug 5, 2021·Journal of Tissue Engineering·Tingting WengXingang Wang

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