Fabrication and drug release study of double-layered microparticles of various sizes

Journal of Pharmaceutical Sciences
Wei Li LeeSay Chye Joachim Loo

Abstract

Double-layered microparticles, composed of poly(D,L-lactide-co-glycolide) (50:50) (PLGA) core and poly(L-lactide) (PLLA) shell, of controllable sizes ranging from several hundred microns to few microns were fabricated using a one-step solvent evaporation method. Metoclopramide monohydrochloride monohydrate (MCA), a hydrophilic drug, was selectively localized in the PLGA core. To achieve the double-layered particles of size approximately 2 µm, the process parameters were carefully manipulated to extend the phase separation time by increasing oil-to-water ratio and saturating the surrounding aqueous phase with solvent. Subsequently, the drug release profiles of the double-layered particles of various sizes were studied. Increased particle size resulted in faster degradation of polymers because of autocatalysis, accelerating the release rate of MCA. Interestingly, the effect of degradation rates, affected by particle sizes, on drug release was insignificant when the particle size was drastically reduced to 2-20 µm in the investigated double-layered particles. This understanding would provide critical insights into how the controllable formation and unique drug release profiles of double-layered particles of various sizes can be ac...Continue Reading

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Citations

Mar 29, 2013·International Journal of Pharmaceutics·Jianzhi ZhouJianxiang Zhang
Feb 13, 2016·Drug Delivery and Translational Research·Sarah TonelloPeter S McFetridge
Dec 3, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoling WangNguan Soon Tan
Jan 29, 2016·Drug Delivery and Translational Research·Rezaul H AnsaryAbd Almonen Doolaanea
Aug 21, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yujie XiaDaniel W Pack
Sep 23, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Natasha YangSay Chye Joachim Loo
May 26, 2020·Macromolecular Rapid Communications·Yi Guang Jerome LimSay Chye Joachim Loo
May 8, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Aharon AzaguryEdith Mathiowitz

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