Fabrication and In Vitro Characterization of Bioactive Glass/Nano Hydroxyapatite Reinforced Electrospun Poly(ε-Caprolactone) Composite Membranes for Guided Tissue Regeneration

Bioengineering
Vishnu Jayakumar SunandhakumariManoj Prasad

Abstract

Current resorbable and non-resorbable membranes act as a physical barrier to avoid connective and epithelial tissue downgrowth into the defect, favoring the regeneration of periodontal tissues. These conventional membranes possess many structural and bio-functional limitations. We hypothesized that the next-generation of guided tissue regeneration (GTR) membranes for periodontal tissue engineering will be a biologically active, spatially designed nanofibrous biomaterial that closely mimics the native extra-cellular matrix (ECM). GTR membranes made of poly(ε-Caprolactone) with a molecular weight of 80,000 reinforced with different weight concentrations of nano-Hydroxyapatite/Bioactive glass (2%, 5%, 10%, 15%) is fabricated by the method of electrospinning. After fabrication, in vitro properties are evaluated. The electrospun nanofibrous membranes possessed excellent mechanical properties initially and after one month of degradation in phosphate buffer solution (PBS). Moreover, none of the fabricated membranes were found to be cytotoxic at lower concentrations and higher concentrations. Comparing the overall properties, PCL (poly(e-caprolactone)) + BG (Bioactive glass) 2% exhibited superior cell attachment and percentage of viabl...Continue Reading

References

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Sep 21, 2005·Journal of Periodontology·Hom-Lay WangUNKNOWN Research, Science and Therapy Committee
Jun 15, 2006·Tissue Engineering·Quynh P PhamAntonios G Mikos
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Apr 7, 2015·Regenerative Biomaterials·Baolin GuoPeter X Ma
Sep 1, 2005·Journal of Periodontology

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BETA
PCL

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Statistical Package for Social Sciences ( SPSS
Optika vision - pro
Image J

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