Fabrication, characterization and comparison of α-arbutin loaded dissolving and hydrogel forming microneedles.

International Journal of Pharmaceutics
Nway Nway AungPraneet Opanasopit

Abstract

In this study, polyacrylic acid-co-maleic acid (PAMA) and polyvinyl alcohol (PVA) (1:4) were used to fabricate dissolving microneedles (DMNs) and hydrogel forming microneedles (HMNs) which incorporated α-arbutin. Αlpha-arbutin is commonly used as a skin lightening agent. However, it has poor penetration ability due to its hydrophilic properties. The purpose of this study was to compare the permeation of α-arbutin into the skin using DMNs and HMNs. Both types of microneedles (MNs) were sharp, strong with elegant appearance and approximately 100% penetrated the neonatal porcine skin. All needles of α-arbutin loaded DMNs were completely dissolved within 45 min, whereas maximum swelling of HMNs was observed at 4 h. In vitro permeation studies showed that α-arbutin loaded DMNs and HMNs provided significantly about 4.5 and 2.8 times, respectively, greater α-arbutin permeability than gel and commercial cream (P < 0.05). In vivo study also showed high intradermal delivery of α-arbutin levels using DMNs (5.33 µg/mL) and HMNs (1.47 µg/mL) when compared to that of commercial cream 0.15 µg/mL. Moreover, the micro-holes caused by applying MNs can reseal within 1 h. MNs were also stable at 25 °C for 3 months. The results suggested that DMNs ...Continue Reading

References

Jan 10, 2008·AAPS PharmSciTech·Francesco CilurzoChiara Sinico
Aug 10, 2010·American Journal of Physiology. Heart and Circulatory Physiology·H K BrekkeT Nedrebø
Jun 7, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jyoti GuptaMark R Prausnitz
May 12, 2012·Advanced Drug Delivery Reviews·Yeu-Chun KimMark R Prausnitz
Nov 13, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Ildikó Y TóthEtelka Tombácz
Nov 13, 2013·Photochemistry and Photobiology·Ryan F DonnellyA David Woolfson
Jun 1, 2014·International Journal of Pharmaceutics·Eneko LarrañetaRyan F Donnelly
Sep 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qing LiuMi Kyeong Lee
Dec 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tayser Sumer GaazAhmed A Al-Amiery
Jun 21, 2017·International Journal of Pharmaceutics·Khalid M El-Say, Hossam S El-Sawy
May 20, 2018·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Boonnada PamornpathomkulRyan F Donnelly
May 26, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hiep X NguyenAjay K Banga
Nov 20, 2018·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Mara LeoneJoke A Bouwstra

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Citations

Mar 17, 2021·Phytotherapy Research : PTR·Majid SaeediHassan Mohammadamini
May 30, 2021·International Journal of Pharmaceutics·Lijing ZhangPeng Zhang
Aug 18, 2021·Journal of Pharmaceutical Sciences·Mohammad F BostanudinAhmad Azfaralariff
Jun 22, 2021·Current Drug Delivery·Mojdeh Rahnama GhahfarokhiBehrooz Movahedi
Sep 17, 2021·International Journal of Pharmaceutics·Kamchai SaepangDoungdaw Chantasart
Jan 11, 2022·Drug Development and Industrial Pharmacy·Jianmin ChenNan Jin

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