Fabrication of alginate-based stimuli-responsive, non-cytotoxic, terpolymric semi-IPN hydrogel as a carrier for controlled release of bovine albumin serum and 5-amino salicylic acid

Materials Science & Engineering. C, Materials for Biological Applications
Dipankar DasInsup Noh

Abstract

Herein, we report a functionalized alginate(Alg)-based terpolymeric semi-interpenetrating (semi-IPN) hydrogel, synthesized via free radical polymerization for the delivery of bovine albumin serum (BSA) and 5-amino salicylic acid (5-ASA). To improve mechanical properties, and to modulate surface morphology of Alg, 2-hydroxyethyl acrylate (HEA) was grafted on alginate and then crosslinked using poly(ethylene glycol) diacrylate (PEGDA). The probable structure and compositions of the synthesized semi-IPN terpolymer were identified by FTIR, 1H-HR-MAS NMR, and TGA analyses. Achievement of equilibrium swelling state (ESS) and higher elastic modulus values confirmed terpolymer gel formation in aqueous media. Differences in the ESS of the prepared gel at pH 2.5 and 7.4 signify its stimuli-responsive behaviour. The influence of PEGDA on swelling, mechanical properties, surface morphology, cell viability and proliferation, and BSA and 5-ASA delivery were characterized. SEM images show that higher % PEGDA resulted in smaller sized pores in the gel network. Texture analyses demonstrate that hardness, adhesiveness and chewiness of the gel were enhanced at higher PEGDA concentrations. Increases in PEGDA concentration also induced increases in...Continue Reading

Citations

Mar 1, 2019·Tissue Engineering and Regenerative Medicine·LeTuyen NguyenInsup Noh
Oct 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yu HuangDong Wang
Jul 6, 2019·International Journal of Biological Macromolecules·Shu-Ya WangGuang-Ming Du
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Anas AhmadRehan Khan
Feb 23, 2021·Frontiers in Chemistry·Yanyu Zhang, Yishun Huang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe CirilloFiore Pasquale Nicoletta
Aug 9, 2021·Carbohydrate Polymers·Yaling DengLei Nie

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