Fabrication of Anti-human Cardiac Troponin I Immunogold Nanorods for Sensing Acute Myocardial Damage.

Nanoscale Research Letters
Zr GuoJn Zhang

Abstract

A facile, rapid, solution-phase method of detecting human cardiac troponin I for sensing myocardial damage has been described using gold nanorods-based biosensors. The sensing is demonstrated by the distinct change of the longitudinal surface plasmon resonance wavelength of the gold nanorods to specific antibody-antigen binding events. For a higher sensitivity, the aspect ratio of gold nanorods is increased up to ca 5.5 by simply adding small amount of HCl in seed-mediated growth solution. Experimental results show that the detecting limit of the present method is 10 ng/mL. Contrast tests reveal that these gold nanorods-based plasmonic biosensors hold much higher sensitivity than that of conventionally spherical gold nanoparticles.

References

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Citations

May 29, 2015·Journal of the American Chemical Society·Yi ShiHong-Yuan Chen
May 21, 2010·Journal of Colloid and Interface Science·Zhirui GuoJinan Zhang
Apr 7, 2017·Scientific Reports·Md AshaduzzamanAshutosh Tiwari
Feb 16, 2018·Analytical and Bioanalytical Chemistry·Tingting BaiXiang Lu
Mar 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhuangzhuang QiaoJianbin Luo
Dec 16, 2020·ACS Biomaterials Science & Engineering·Suliman KhanMojtaba Falahati
Apr 12, 2017·ACS Applied Materials & Interfaces·Panchanathan ManivasaganJunghwan Oh

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
ELISA
surface
biosensing
biosensors

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