Fabrication of biomimetic bone grafts with multi-material 3D printing

Biofabrication
Nicholas A SearsElizabeth Cosgriff-Hernandez

Abstract

Extrusion deposition is a versatile method for the 3D printing of biomaterials such as hydrogels, ceramics, and suspensions. Recently, a new class of emulsion inks were developed that can be used to create tunable, hierarchically porous materials with a cure-on-dispense method. Propylene fumarate dimethacrylate (PFDMA) was selected to fabricate bone grafts using this technology due to its established biocompatibility, osteoconductivity, and good compressive properties. Scaffolds fabricated from PFDMA emulsion inks displayed compressive modulus and yield strength of approximately 15 and 1 MPa, respectively. A decrease in infill (from 100% to 70%) resulted in a six-fold increase in permeability; however, there was also a corollary decrease in mechanical properties. In order to generate scaffolds with increased permeability without sacrificing mechanical strength, a biomimetic approach to scaffold design was used to reinforce the highly porous emulsion inks with a dense cortical shell of thermoplastic polyester. Herein, we present an open source method for printing multi-material bone grafts based on PFDMA polyHIPEs with hierarchical porosity and reinforced with a dense shell of poly(ε-caprolactone) (PCL) or poly(lactic acid) (PLA...Continue Reading

References

Sep 1, 1970·Journal of Biomedical Materials Research·S F HulbertF H Stelling
Oct 18, 2000·Journal of Biomedical Materials Research·Q M JinY Kuboki
Nov 18, 2000·Genome Génome / Conseil National De Recherches Canada·T R Gregory
Jan 5, 2002·Journal of Biomedical Materials Research·John P FisherJohn A Jansen
Mar 19, 2004·Journal of Biomaterials Science. Polymer Edition·Yoshitake Takahashi, Yasuhiko Tabata
Jul 28, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Uwe GbureckJake E Barralet
Nov 21, 2007·Journal of Biomechanics·Etienne MalachanneFranck Jourdan
Apr 23, 2008·Journal of Biomedical Materials Research. Part a·Amit S MistryAntonios G Mikos
Feb 5, 2009·Journal of Biomedical Materials Research. Part a·Amit S MistryJohn A Jansen
Aug 25, 2011·Biomacromolecules·Robert S MogliaElizabeth Cosgriff-Hernandez
Mar 1, 2012·Journal of Biomechanics·M R DiasS J Hollister
Sep 4, 2012·Journal of Biomedical Materials Research. Part a·Sean V MurphyAnthony Atala
May 15, 2013·Acta Biomaterialia·S J PolakA J Wagoner Johnson
Oct 15, 2013·Biomedical Engineering Online·Andrea D MuschenbornDuncan J Maitland
Oct 16, 2013·Tissue Engineering. Part a·Jennifer L RobinsonElizabeth Cosgriff-Hernandez
Jul 10, 2014·Biomacromolecules·Robert S MogliaElizabeth Cosgriff-Hernandez
Aug 6, 2014·Nature Biotechnology·Sean V Murphy, Anthony Atala
Apr 14, 2015·Journal of Biological Engineering·Helena N Chia, Benjamin M Wu
Nov 13, 2015·Biomaterials·Ibrahim T Ozbolat, Monika Hospodiuk
Jan 8, 2016·Tissue Engineering. Part a·Jennifer RobinsonElizabeth Cosgriff-Hernandez
Jun 12, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ai-Juan WangFrederik Claeyssens
Jun 16, 2016·Macromolecular Rapid Communications·Nicholas A SearsElizabeth M Cosgriff-Hernandez
Nov 7, 2017·ACS Biomaterials Science & Engineering·Michael E WhitelyElizabeth Cosgriff-Hernandez
Mar 16, 2006·Soft Matter·Angelika MennerAlexander Bismarck

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Citations

Dec 29, 2017·Advanced Healthcare Materials·Jesse K Placone, Adam J Engler
Mar 14, 2019·The Journal of Craniofacial Surgery·Ivan Onone GialainArthur Rodriguez Gonzalez Cortes
Jul 14, 2019·The Journal of Craniofacial Surgery·Ivan Onone GialainArthur Rodriguez Gonzalez Cortes
Jul 1, 2020·Advanced Science·Mohammad RafieeDaniel Therriault
Feb 7, 2020·International Journal of Oral Science·Lisha ZhuYan Liu
May 31, 2019·Tissue Engineering. Part B, Reviews·Reza MasaeliLobat Tayebi
Mar 11, 2020·Regenerative Biomaterials·Dewei Zhao, Zhijie Ma
Apr 25, 2020·Tissue Engineering. Part C, Methods·Luis Diaz-GomezAntonios G Mikos
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jibao ZhengLing Wang
Aug 27, 2021·Biomedical Physics & Engineering Express·Maedeh RahimnejadRodrigo França
Dec 10, 2021·Advanced Healthcare Materials·Joseph Christakiran MosesBiman B Mandal

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