Fabrication of biomimetic vascular scaffolds for 3D tissue constructs using vascular corrosion casts

Acta Biomaterialia
Jennifer HulingJames J Yoo

Abstract

Vascularization is among the most pressing technical challenges facing tissue engineering of 3D organs. While small engineered constructs can rely solely on vascular infiltration and diffusion from host tissues following implantation, larger avascular constructs do not survive long enough for vessel ingrowth to occur. To address this challenge, strategies for pre-vascularization of engineered constructs have been developed. Various biofabrication techniques have been utilized for pre-vascularization, but limitations exist with respect to the size and complexity of the resulting vessels. To this end, we developed a simple and novel fabrication method to create biomimetic microvascular scaffolds using vascular corrosion casting as a template for pre-vascularization of engineered tissue constructs. Gross and electron microscopic analysis demonstrates that polycaprolactone (PCL)-derived kidney vascular corrosion casts are able to capture the architecture of normal renal tissue and can serve as a sacrificial template for the creation of a collagen-based vascular scaffold. Histological analysis demonstrates that the collagen vascular scaffolds are biomimetic in structure and can be perfused, endothelialized, and embedded in hydrogel ...Continue Reading

References

Jan 1, 1992·Anatomy and Embryology·S AharinejadA Lametschwandtner
Apr 1, 1996·Biomaterials·L H Olde DaminkJ Feijen
Oct 19, 2002·Molecular Aspects of Medicine·Masashi NomiShay Soker
Nov 5, 2005·Biotechnology and Bioengineering·Milica RadisicGordana Vunjak-Novakovic
May 5, 2007·Scanning·Flaviana Dornela VerliMaria Antonieta Lopes de Souza
Sep 22, 2007·Biotechnology Advances·In-Yong KimChong-Su Cho
Oct 18, 2007·Biopolymers·Julie Glowacki, Shuichi Mizuno
Feb 26, 2008·The Journal of Urology·Helio J S Bagetti FilhoFrancisco J B Sampaio
Oct 11, 2008·Methods : a Companion to Methods in Enzymology·Akira JorakuJames J Yoo
Dec 17, 2008·Biomaterials·Weining Bian, Nenad Bursac
Mar 25, 2009·Tissue Engineering. Part B, Reviews·Tamar KaullyShulamit Levenberg
Jun 6, 2009·Tissue Engineering. Part B, Reviews·Michael LovettDavid L Kaplan
Mar 26, 2011·Advanced Materials·Willie WuJennifer A Lewis
Nov 5, 2011·Journal of Tissue Engineering and Regenerative Medicine·Shuang Hong LüChang Yong Wang
Jan 31, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadia K Guimaraes-SouzaJames J Yoo
Apr 3, 2012·Advanced Materials·James C CulverMary E Dickinson
Apr 5, 2013·Advanced Healthcare Materials·Jiankang HeDichen Li
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jan D BaranskiChristopher S Chen
Oct 26, 2013·Tissue Engineering. Part a·Ingra VollertThomas Eschenhagen
Feb 20, 2014·Advanced Materials·David B KoleskyJennifer A Lewis
May 27, 2014·Lab on a Chip·Luiz E BertassoniAli Khademhosseini
Jun 8, 2014·Biomaterials·Anwarul HasanAli Khademhosseini

❮ Previous
Next ❯

Citations

Jun 2, 2016·Journal of Cardiovascular Translational Research·Cristiano SpadaccioAlberto Rainer
Aug 6, 2011·PloS One·Anne RiemannMichael Gekle
Sep 26, 2016·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·M-O TimsitF Kleinclauss
Mar 21, 2017·Regenerative Medicine·Kristina Haase, Roger D Kamm
Oct 13, 2017·Stem Cells Translational Medicine·Jan AdamowiczTomasz Drewa
May 12, 2018·MRS Communications·Christian MandryckyYing Zheng
Jul 13, 2019·Vascular Specialist International·Sangil MinJames J Yoo
Dec 11, 2019·Neurourology and Urodynamics·Christopher ChermanskyApostolos Apostolidis
Feb 27, 2020·Advanced Healthcare Materials·Shantanu PradhanJohn H Slater
Sep 8, 2020·Advanced Healthcare Materials·Joe Tien, Yoseph W Dance
Dec 21, 2017·Inflammation and Regeneration·Sachiko Sekiya, Tatsuya Shimizu
Jan 5, 2019·Nature Reviews. Nephrology·Noemie Jourde-ChicheLubka T Roumenina
Jul 12, 2018·Scientific Reports·Jan SchönebergHorst Fischer
Jan 12, 2021·Bio-design and Manufacturing·Pengju WangHaitao Liu
Jul 3, 2021·Biomimetics·Charlotta G Lebedenko, Ipsita A Banerjee
Aug 5, 2021·Journal of Tissue Engineering·Tingting WengXingang Wang
Oct 10, 2016·ACS Biomaterials Science & Engineering·Afonso MalheiroLorenzo Moroni
Sep 18, 2018·ACS Applied Materials & Interfaces·Rangika Thilan De SilvaK M Nalin de Silva

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