Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic levitational assembly.

Scientific Reports
Vladislav A ParfenovVladimir S Komlev

Abstract

The calcium phosphate particles can be used as building blocks for fabrication of 3D scaffolds intended for bone tissue engineering. This work presents for the first time a rapid creation of 3D scaffolds using magnetic levitation of calcium phosphate particles. Namely, tricalcium phosphate particles of equal size and certain porosity are used, which undergo the process of recrystallization after magnetic levitational assembly of the scaffold to ensure stitching of the scaffold. Label-free levitational assembly is achieved by using a custom-designed magnetic system in the presence of gadolinium salts, which allows the levitation of calcium phosphate particles. Chemical transformation of tricalcium- to octacalcium phosphate under the condition of magnetic levitation in non-homogeneous magnetic field is also demonstrated. This approach allows obtaining rapidly the octacalcium phosphate phase in the final 3D product, which is biocompatible.

References

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Citations

Aug 31, 2020·Trends in Biotechnology·Ali Akbar Ashkarran, Morteza Mahmoudi
Jul 19, 2020·Applied and Environmental Microbiology·Pavel DomninSvetlana Ermolaeva

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Methods Mentioned

BETA
X-ray
Fluorescence
light microscopy
fluorescence microscopy
flow cytometry

Software Mentioned

COMSOL
GraphPad Prism
MagLev
COMSOl “ Particle Tracing Module

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