Fabrication of chitosan/polyvinylpyrrolidone hydrogel scaffolds containing PLGA microparticles loaded with dexamethasone for biomedical applications.

International Journal of Biological Macromolecules
Sadaf Saeedi GarakaniMaryam Jalessi

Abstract

One of the most effective approaches for treatment of chronic rhinosinusitis is the use of hydrogel scaffolds with the sustained release of a given required drug. With this in mind, first, we synthesized and characterized poly (lactide-co-glycolide) (PLGA) micro and nano particles loaded with dexamethasone (DEX). We observed a 7-day release of DEX from nanoparticles, while the microparticles showed a 22-day release profile. Due to their slower rate of release, the PLGA microparticles loaded with DEX (PLGADEX microparticles) were specifically chosen for this study. As a second step, chitosan/polyvinylpyrrolidone (PVP) based hydrogels were prepared in various weight ratios and the PLGADEX microparticles were optimized in their structure based on variable gelation times. The morphological studies showed PLGADEX microparticles homogenously dispersed in the hydrogels. Moreover, the effect of weight ratio in the presence and absence of optimum percentage of PLGADEX microparticles was studied. The resultant hydrogels demonstrated a range of advantages, including good mechanical strength, porous morphology, amorphous structure, high swelling ratio, controlled biodegradability rate, and antibacterial activity. Additionally, a cytotoxici...Continue Reading

Citations

Feb 13, 2021·International Journal of Molecular Sciences·Luis Castillo-HenríquezJosé Vega-Baudrit
Jan 18, 2021·International Journal of Biological Macromolecules·Saman Emami GeramiMona Navaei Nigjeh
Feb 24, 2021·International Journal of Biological Macromolecules·Leila Yavari Maroufi, Marjan Ghorbani
Apr 4, 2021·Polymers·M Sai Bhargava ReddyKishor Kumar Sadasivuni
Apr 14, 2021·Journal of Pharmaceutical Sciences·Mariam ZewailNabila Boraie
Jul 5, 2021·International Journal of Biological Macromolecules·Hadi RahnamaShahla Khalili

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