Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells

Journal of Colloid and Interface Science
Murali Mohan YallapuSubhash C Chauhan

Abstract

Curcumin, a natural polyphenolic compound, has shown promising chemopreventive and chemotherapeutic activities in cancer. Although phase I clinical trials have shown curcumin as a safe drug even at high doses, poor bioavailability and suboptimal pharmacokinetics largely moderated its anti-cancer activity in pre-clinical and clinical models. To improve its applicability in cancer therapy, we encapsulated curcumin in poly(lactic-co-glycolide) (PLGA) (biodegradable polymer) nanoparticles, in the presence of poly(vinyl alcohol) and poly(L-lysine) stabilizers, using a nano-precipitation technique. These curcumin nano-formulations were characterized for particle size, zeta potential, drug encapsulation, drug compatibility and drug release. Encapsulated curcumin existed in a highly dispersed state in the PLGA core of the nanoparticles and exhibited good solid-solid compatibility. An optimized curcumin nano-formulation (nano-CUR6) has demonstrated two and sixfold increases in the cellular uptake performed in cisplatin resistant A2780CP ovarian and metastatic MDA-MB-231 breast cancer cells, respectively, compared to free curcumin. In these cells, nano-CUR6 has shown an improved anti-cancer potential in cell proliferation and clonogenic ...Continue Reading

References

Feb 11, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·T GovenderS S Davis
Sep 3, 2002·Advanced Drug Delivery Reviews·Irène BriggerPatrick Couvreur
Oct 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina FonsecaRogério Gaspar
Feb 22, 2005·Critical Reviews in Therapeutic Drug Carrier Systems·Indu BalaM N V Ravi Kumar
Nov 23, 2006·Advanced Drug Delivery Reviews·Wassim AbdelwahedHatem Fessi
Jan 2, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Kristin R Landis-PiwowarQ Ping Dou
Mar 14, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·G MittalM N V Ravi Kumar
Jul 7, 2007·Journal of Drug Targeting·Stefano SalmasoPaolo Caliceti
Jul 25, 2007·Current Problems in Cancer·Shishir ShishodiaBharat B Aggarwal
Jul 27, 2007·Drug Development and Industrial Pharmacy·Vjera Grabovac, Andreas Bernkop-Schnürch
Oct 28, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
Feb 6, 2009·Expert Review of Anticancer Therapy·Patrick G Morris, Monica N Fornier
Feb 25, 2009·The Analyst·Bryce J MarquisChristy L Haynes
Jul 9, 2009·Cancer Prevention Research·Elena P Moiseeva, Margaret M Manson
May 12, 2010·Colloids and Surfaces. B, Biointerfaces·Murali Mohan YallapuSubhash C Chauhan

❮ Previous
Next ❯

Citations

Oct 5, 2011·Cancer Chemotherapy and Pharmacology·Liu ZhongfaKenneth K Chan
Sep 29, 2011·Applied Biochemistry and Biotechnology·Alicia Fernandez-FernandezAnthony J McGoron
Nov 5, 2011·Expert Reviews in Molecular Medicine·Abdenour BelkacemiCharles Ramassamy
Aug 10, 2010·Journal of Ovarian Research·Murali M YallapuSubhash C Chauhan
Jul 23, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Saeed ManoochehriRassoul Dinarvand
Jul 2, 2011·International Journal of Nanomedicine·R DinarvandF Atyabi
Dec 1, 2011·International Journal of Nanomedicine·Murali Mohan YallapuSubhash C Chauhan
Feb 22, 2012·International Journal of Nanomedicine·Imtiaz A SiddiquiHasan Mukhtar
May 30, 2013·International Journal of Nanomedicine·Amit Kumar SrivastavaKailash Chand Gupta
May 24, 2012·International Journal of Nanomedicine·Murali M YallapuSubhash C Chauhan
Jun 30, 2012·International Journal of Nanomedicine·Yin-Meng TsaiTung-Hu Tsai
Aug 6, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Sue Ping LimDavid F Callen
Feb 16, 2013·International Journal of Biological Sciences·Keita HayashiHiroshi Umakoshi
Aug 1, 2012·Nanomedicine·Min SunGuangxi Zhai
Sep 26, 2013·Pharmaceutical Research·Peng ZouDuxin Sun
May 24, 2014·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Aditya GanjuMeena Jaggi
Aug 1, 2011·Drug Delivery and Translational Research·Bhushan MunjalArvind Kumar Bansal
Sep 4, 2015·Pharmaceutical Development and Technology·Harish PawarSarasija Suresh
Nov 28, 2014·International Journal of Molecular Sciences·Katarzyna M TerlikowskaSlawomir J Terlikowski
May 27, 2014·Expert Opinion on Drug Delivery·Wing-Hin LeeRamin Rohanizadeh
Jan 19, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mina MehannySamar Mansour
Sep 18, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Fatemeh Sadat Tabatabaei MirakabadMohammad Rahmati-Yamchi
May 7, 2011·Journal of Pharmaceutical Sciences·Komal Shahani, Jayanth Panyam
Dec 17, 2015·Experimental and Therapeutic Medicine·Jun GuoAi-Qing Yang
Feb 4, 2016·Scientific Reports·Mohd S ZamanSubhash C Chauhan
Jan 11, 2014·The Journal of Nutritional Biochemistry·Shu WangNaima Moustaid-Moussa
Mar 10, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vivek S JavalkotePrashant K Deshmukh
Mar 27, 2015·Journal of Biomolecular Structure & Dynamics·Seifollah Jalili, Marzieh Saeedi
Jan 12, 2013·Journal of Colloid and Interface Science·Ning WangChen Guo
Dec 4, 2012·Colloids and Surfaces. B, Biointerfaces·Parvin Zakeri-MilaniHadi Valizadeh
Oct 1, 2011·Drug Discovery Today·Murali M YallapuSubhash C Chauhan
Jul 7, 2011·International Journal of Pharmaceutics·Yin-Meng TsaiTung-Hu Tsai
Mar 19, 2011·Drug Discovery Today·Murali Mohan YallapuSubhash C Chauhan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis