Fabrication of gelatin-strontium substituted calcium phosphate scaffolds with unidirectional pores for bone tissue engineering

Journal of Materials Science. Materials in Medicine
Yu-Chun WuTzer-Min Lee

Abstract

This study fabricated homogeneous gelatin-strontium substituted calcium phosphate composites via coprecipitation in a gelatin solution. Unidirectional porous scaffolds with an oriented microtubular structure were then manufactured using freeze-drying technology. The resulting structure and pore alignment were determined using scanning electron microscopy. The pore size were in the range of 200-400 μm, which is considered ideal for the engineering of bone tissue. The scaffolds were further characterized using energy dispersive spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction. Hydroxyapatite was the main calcium phosphate compound in the scaffolds, with strontium incorporated into the crystal structure. The porosity of the scaffolds decreased with increasing concentration of calcium-phosphate. The compressive strength in the longitudinal direction was two to threefold higher than that observed in the transverse direction. Our results demonstrate that the composite scaffolds degraded by approximately 20 % after 5 weeks. Additionally, in vitro results reveal that the addition of strontium significantly increased human osteoblastic cells proliferation. Scaffolds containing strontium with a Sr-CaP/(gelatin...Continue Reading

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Citations

Dec 18, 2015·Journal of Materials Science. Materials in Medicine·Natalia DavidenkoRuth E Cameron
May 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Ming-Hsien HuangMing-You Shie
Jan 23, 2019·Journal of Tissue Engineering and Regenerative Medicine·Uresha PatelVirginie Sottile
Apr 4, 2021·Gels·I-Hao ChenChih-Ling Huang
May 25, 2021·Bioengineering & Translational Medicine·Sijing JiangJiacai He

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