Fabrication of Hexagonal-Prismatic Granular Hydrogel Sheets

Langmuir : the ACS Journal of Surfaces and Colloids
Huachuan DuEsther Amstad

Abstract

Natural soft materials are often composed of proteins that self-assemble into well-defined structures and display mechanical properties that cannot be matched by manmade materials. These materials are frequently mimicked with hydrogels whose mechanical properties depend on their composition and the type and density of cross-links. Protocols to tune these parameters are well established and routinely used. The mechanical properties of hydrogels also depend on their structure; this parameter is more difficult to control. In this paper, we present a method to produce hexagonal-prismatic granular hydrogel sheets with well-defined structures and heterogeneous cross-link densities. The hydrogel sheets are made of self-assembled covalently cross-linked 40-120 μm diameter hexagonal-prismatic hydrogel particles that display a narrow size distribution. The structure and microscale surface roughness of the hydrogels sheets can be tuned with the polymerization conditions, their chemical composition with that of the individual hydrogel particles, and their mechanical properties with the cross-link density. Remarkably, the hydrogels composed of hexagonal-prismatic microparticles are significantly stiffer than unstructured counterparts. These...Continue Reading

References

Nov 27, 2002·Langmuir : the ACS Journal of Surfaces and Colloids·A RevzinM V Pishko
Mar 9, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Sakiko Tsuji, Haruma Kawaguchi
Jul 14, 2005·Journal of the American Chemical Society·Jason P RollandJoseph M DeSimone
Apr 19, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Masafumi KumodaYukikazu Takeoka
Jul 11, 2006·Biomaterials·Judy YehAli Khademhosseini
Dec 7, 2007·The Journal of Experimental Biology·Matthew J Harrington, J Herbert Waite
Sep 25, 2008·Lab on a Chip·C HoltzeD A Weitz
Oct 14, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Stephan SchmidtRegine von Klitzing
Sep 11, 2009·The Journal of Chemical Physics·D QuigleyD M Duffy
Sep 8, 2012·Nature·Jeong-Yun SunZhigang Suo
Dec 15, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Zouheir Drira, Vamsi K Yadavalli
May 3, 2013·Nano Letters·Manu S MannoorMichael C McAlpine
Jun 25, 2013·Journal of Structural Biology·Jason R Dorvee, Arthur Veis
Aug 1, 2013·Nature Communications·Lie-Wen XiaLiang-Yin Chu
Apr 29, 2014·Analytical Chemistry·Zhongyu CaiSanford A Asher
Aug 6, 2014·Nature Biotechnology·Sean V Murphy, Anthony Atala
Oct 11, 2014·Angewandte Chemie·Elena DegtyarPeter Fratzl
Aug 1, 2015·Biochimica Et Biophysica Acta·Benjamin J Lopez, Megan T Valentine
Sep 1, 2015·Nature Materials·Scott C GrindyNiels Holten-Andersen
Sep 16, 2015·Pharmaceutics·Rachel Shet Hui WongKalliopi Dodou
Oct 21, 2015·Angewandte Chemie·Zhongyu CaiSanford A Asher
Dec 10, 2015·ACS Nano·Qiaochu LiNiels Holten-Andersen
Oct 19, 2016·Lab on a Chip·E AmstadD A Weitz
Mar 7, 2017·Nature Communications·Tobias PriemelMatthew J Harrington
Apr 14, 2017·Nature·Liana ManukyanMichel C Milinkovitch
Jan 7, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sineenat ThaiboonrodBrian R Saunders

❮ Previous
Next ❯

Citations

May 14, 2019·Advanced Materials·Gianluca EtienneEsther Amstad
Oct 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lingzhi CaiP-T Brun
Mar 26, 2021·ACS Applied Materials & Interfaces·Mathias SteinacherEsther Amstad
Jul 13, 2021·Soft Matter·Céline Samira WyssDominique P Pioletti
Aug 3, 2021·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Esther Amstad, Matthew J Harrington

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.