Fabrication of hyaluronidase-responsive biocompatible multilayers on BMP2 loaded titanium nanotube for the bacterial infection prevention

Materials Science & Engineering. C, Materials for Biological Applications
Linawati SutrisnoKaiyong Cai

Abstract

Infection associated with orthopedic implants is the chief cause of implant failure. An important consideration to prevent the infection at implants is to inhibit the biofilm formation for the initial 6 h. Therefore, we fabricated hyaluronidase-sensitive multilayers of chitosan (Chi)/sodium hyaluronate-lauric acid (SL) onto the surface of bone morphogenetic protein 2 (BMP2) loaded titanium nanotube (TNT) via spin-assisted layer-by-layer technique. The results of both Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H NMR) confirmed the successful synthesis of SL. The multilayer structure on BMP2 loaded TNT was characterized by field-emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) and water contact angle, respectively. The release profiles confirmed that hyaluronidase could trigger the release of lauric acid (LA) from the SL multilayer and accelerate the release of BMP2 in the system. The hyaluronidase-sensitive-multilayer-coated BMP2-loaded TNT (TNT/BMP2/(Chi/SL/Chi/Gel)4) not only demonstrated good antibacterial capability, but also showed good biocompatibility in in vitro usage, which was supported by the efficient growth inhibition of both Staphylococcus aureus and...Continue Reading

Citations

Feb 23, 2020·Annual Review of Biomedical Engineering·Dahlia AlkekhiaAnita Shukla
Aug 28, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Linawati SutrisnoKaiyong Cai
Jan 28, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Anqi LiJianshu Li
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Clara I ColinoCarmen Gutierrez-Millan
May 5, 2021·Drug Delivery and Translational Research·Kun WangPeng Li

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