Fabrication of interdigitated micropatterns of self-assembled polymer nanofilms containing cell-adhesive materials

Langmuir : the ACS Journal of Surfaces and Colloids
Javeed Shaikh MohammedM J McShane

Abstract

Micropatterns of different biomaterials with micro- and nanoscale features and defined spatial arrangement on a single substrate are useful tools for studying cellular-level interactions, and recent reports have highlighted the strong influence of scaffold compliance in determining cell behavior. In this paper, a simple yet versatile and precise patterning technique for the fabrication of interdigitated micropatterns of nanocomposite multilayer coatings on a single substrate is demonstrated through a combination of lithography and layer-by-layer (LbL) assembly processes, termed polymer surface micromachining (PSM). The first nanofilm pattern is constructed using lithography, followed by LbL multilayer assembly and lift-off, and the process is repeated with optical alignment to obtain interdigitated patterns on the same substrate. Thus, the method is analogous to surface micromachining, except that the deposition materials are polymers and biological materials that are used to produce multilayer nanocomposite structures. A key feature of the multilayers is the capability to tune properties such as stiffness by appropriate selection of materials, deposition conditions, and postdeposition treatments. Two- and four-component system...Continue Reading

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Citations

Dec 22, 2009·Chemical Communications : Chem Comm·Albert LiberskiMark Bradley
Nov 10, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Malte Burchardt, Gunther Wittstock
May 1, 2012·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jameel Shaik, David K Mills
Mar 11, 2010·Advanced Materials·Thomas BoudouCatherine Picart
Jan 1, 2013·Journal of Medical Engineering·Jameel ShaikDavid K Mills
Nov 8, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Javeed Shaikh Mohammed, Mike McShane
Apr 16, 2009·Nano Letters·Albert J SwistonMichael F Rubner
Jun 10, 2010·Biomacromolecules·Albert J SwistonMichael F Rubner
Aug 28, 2010·Biomacromolecules·Fernando C VasconcellosMichael F Rubner

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