Fabrication of isradipine nanosuspension by anti-solvent microprecipitation-high-pressure homogenization method for enhancing dissolution rate and oral bioavailability

Drug Delivery and Translational Research
Dnyanesh B ShelarPradeep R Vavia

Abstract

The aim of this study was to develop a nanosuspension of a highly hydrophobic drug, isradipine (ISR) by combination of anti-solvent microprecipitation and high-pressure homogenization to achieve the superior in vitro dissolution and in vivo pharmacokinetic profile. The nanosuspension was formulated using combination of stabilizers as vitamin E TPGS and sodium lauryl sulfate. The developed nanosuspension was characterized for particle size, shape, and zeta potential. The particle size of the developed ISR nanosuspension was observed to be approximately 538 nm (by laser diffraction) and 469 nm (by photon correlation spectroscopy) with -33.3 mV zeta potential. Scanning electron microscopy study revealed the good correlation with particle size measured by photon correlation spectroscopy and laser diffraction. The X-ray diffraction and differential scanning calorimetry showed that ISR was present as an amorphous state in the lyophilized form of nanosuspension. In vitro dissolution and saturation solubility study showed the dissolution rate of nanosuspensions (98.60 %) and saturation solubility (98.76 μg/ml) compared with the coarse drug (11.53 % and 14.1 μg/ml, respectively) had been significantly enhanced. The pharmacokinetic study...Continue Reading

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Citations

Oct 24, 2013·International Journal of Pharmaceutics·Biswadip SinhaJan P Möschwitzer
May 12, 2016·Drug Delivery and Translational Research·Om Prakash SharmaTejal Mehta
May 22, 2016·Drug Delivery and Translational Research·Yaya LeiWenping Wang
Apr 2, 2017·Drug Delivery and Translational Research·Wenqian YangZhonggui He
Jul 28, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Daoxiao ChangWenping Wang
Jan 1, 2014·Journal of Pharmaceutics·Jaime SalazarJan P Möschwitzer
Jul 1, 2019·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Sravanthi Reddy PaillaSunitha Sampathi
May 17, 2021·International Journal of Pharmaceutics·Vivek VermaLuis Padrela

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