Fabrication of large-area ordered and reproducible nanostructures for SERS biosensor application

The Analyst
Gobind DasMarco Salerno

Abstract

We propose a large-area SERS device with efficient fluorescence quenching capability. The substrate is based on anodic porous alumina templates with various pore size and wall thickness as small as 15 and 36 nm, respectively. The nano-patterned SERS substrate, with excellent control and reproducibility of plasmon-polaritons generation, shows very efficient enhanced Raman signal in the presence of intrinsically fluorescent molecules such as cresyl violet, rhodamine, and green fluorescent protein. This work demonstrates that, when the nanostructures are properly designed and fabricated, Raman and fluorescence spectroscopy can be used in combination in order to obtain complementary molecular informations. Theoretical simulation shows excellent agreement with the experimental findings. The enhancement factor is found to be 10(3)-10(4), with respect to flat gold surface when the molecules are supposed to be closely packed, with considerable fluorescence suppression, showing a promising disposable biosensor.

References

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Nov 4, 2008·Biosensors & Bioelectronics·Gobind DasEnzo Di Fabrizio
Jan 1, 2009·Nanoscale Research Letters·Marco SalernoRoberto Cingolani

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Citations

Feb 28, 2014·Journal of Materials Science. Materials in Medicine·Chiara ToccafondiGobind Das
Jan 24, 2014·Advanced Materials·Manohar ChirumamillaEnzo Di Fabrizio
Dec 1, 2012·Physical Chemistry Chemical Physics : PCCP·R IntartagliaF Brandi
Mar 4, 2015·TheScientificWorldJournal·Thomas Grosges, Dominique Barchiesi
Apr 20, 2019·Biosensors·Roberto PilotLaura Fabris
Oct 11, 2013·Physical Chemistry Chemical Physics : PCCP·Scott G HarrounRobert D Singer
Feb 3, 2016·Optics Express·S Z OoM D B Charlton
Jan 27, 2018·Physical Chemistry Chemical Physics : PCCP·Reem Ahmed KaraballiChrista L Brosseau
Jun 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kostiantyn TurcheniukSabine Szunerits
May 19, 2018·Materials·Giovanni MarinaroEnzo Di Fabrizio
Apr 4, 2021·Materials·Katarzyna SkibińskaPiotr Żabiński
May 23, 2014·Nano Letters·A NazirA Toma

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