Fabrication of monodisperse, large-sized, functional biopolymeric microspheres using a low-cost and facile microfluidic device

Biomedical Microdevices
Liping ZhuMeifang Zhu

Abstract

We report a novel and facile method for fabricating coaxial microfluidic devices processing various dimensions at low cost, in which polypropylene hollow fibers or glass capillaries are used as the tip of the dispersed phase injection tube. With this coaxial microfluidic device,monodisperse biocompatible microspheres ranging from 300 to 800 μm were obtained by collecting oil-in-water or water-in-oil emulsions and solidifying the suspended microspheres. Microsphere size could be controlled by changing the tips or tuning the concentrations of the dispersed and continuous phases. By adding functional nanoparticles into the dispersed phase, it was demonstrated that fluorescent and magnetic microspheres can be fabricated easily using these microfluidic devices.

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Citations

Feb 12, 2013·Nanomedicine·José Carlos De La VegaUrs O Häfeli
Aug 13, 2013·Advanced Drug Delivery Reviews·Stefania MazzitelliClaudio Nastruzzi
Dec 18, 2013·Tissue Engineering. Part B, Reviews·Carlos Filipe C JoãoJoão Paulo Borges
Oct 10, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min GeJun Yang

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