Fabrication of N-doped multidimensional carbon nanofibers for high-performance cortisol biosensors

Biosensors & Bioelectronics
Goeen JeongJyongsik Jang

Abstract

Cortisol is an hormone that regulates blood pressure, glucose levels and carbohydrate metabolism in humans. Abnormal secretion of cortisol can cause various symptoms closely linked to psychological and physical health. In this study, high-performance field-effect transistor (FET)-based biosensors for cortisol detection were fabricated from N-doped multidimensional carbon nanofibers. Nanofiber morphology was controlled by tailoring the pressure conditions during vapor deposition polymerization (VDP). Thereafter, conductive channels of FET were completed by thermal annealing, acid treatment, and antibody attachment. Changes associated with chemical processes were characterized by various instruments. The resulting transducers exhibited a rapid response toward cortisol molecules with accurate selectivity, stable reusability, and high sensitivity. Minimum detection level were as low as 100 aM with a wide linear detection range of 100 aM to 10 nM due to the large surface area of the transducer and a correspondingly high number of antibody labels. The response and applicability of these cortisol biosensors were also assessed using saliva as a test matrix.

Citations

Nov 2, 2019·Biosensors·Paloma Yáñez-SedeñoJosé Manuel Pingarrón
Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xinghua LiHongmei Shi
Mar 17, 2020·Analytical and Bioanalytical Chemistry·Nicole Jaffrezic-RenaultZhenzhong Guo
Dec 10, 2020·International Journal of Molecular Sciences·Alexandra Virginia Bounegru, Constantin Apetrei
Jan 29, 2021·Communications Materials·Shokoofeh SheibaniAdrian M Ionescu
Mar 23, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ghada G AbdoAhmed A Elzatahry

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