Fabrication of Nanocomposites Complexed with Gold Nanoparticles on Polyaniline and Application to Their Nerve Regeneration.

ACS Applied Materials & Interfaces
Hye Jin KimKeun-Hong Park

Abstract

Electrically conductive materials can stimulate stem cells through electric shock and thereby contribute to the regulation of cell proliferation and differentiation. Recently, polymer-metal complexes composed of polyaniline and gold nanoparticles have emerged as novel candidates for use in regenerative medicine. By mixing two different materials, such composites maximize the benefits while alleviating the disadvantages of using either material alone. Based on their excellent conductivity, these complexes can be applied to nerve regeneration using stem cells. In this study, we investigated a method for producing hybrid nanocomposites by complexing gold nanoparticles to polyaniline and tested the resultant composites in a model of nerve regeneration. We manipulated the shape, size, and electrical conductivity of the hybrid composites by compounding the component materials at various ratios. The most efficient nanocomposite was named conductive reinforced nanocomposites (CRNc's). When the CRNc was delivered directly to cells, no cytotoxicity was observed. After the intracellular delivery of the CRNc, the stem cells were electrically stimulated using an electroporator. As a result of performing mRNA-sequencing (Seq) analysis after ...Continue Reading

References

Aug 31, 1999·Biophysical Journal·K A DeBruin, W Krassowska
Apr 20, 2006·Ultrasonics Sonochemistry·Xinli JingJipeng Qiang
Jul 21, 2006·Chemical Communications : Chem Comm·Jun WangHsian-Rong Tseng
Dec 4, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ji Sun ParkKeun-Hong Park
Apr 16, 2013·Biochimica Et Biophysica Acta·Yu-Jung ChangLinyi Chen
Feb 15, 2014·Human Molecular Genetics·Christina R MuratoreTracy L Young-Pearse
Sep 29, 2015·Journal of Nanoscience and Nanotechnology·Saji Alex, Ashutosh Tiwari
Jan 11, 2018·Scientific Reports·Petr HumpolíčekJaroslav Stejskal
Feb 23, 2018·Journal of Colloid and Interface Science·Yaobin WuBaolin Guo
Apr 24, 2018·Biomacromolecules·Baolin Guo, Peter X Ma
Nov 11, 2019·Biomaterials·Ruonan DongBaolin Guo

❮ Previous
Next ❯

Citations

Oct 4, 2020·Journal of Tissue Engineering and Regenerative Medicine·Umran Aydemir SezerHuseyin Karaca
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee
May 18, 2021·Bioactive Materials·Wen XueBin Duan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.