Fabrication of novel bioactive hydroxyapatite-chitosan-silica hybrid scaffolds: Combined the sol-gel method with 3D plotting technique

Carbohydrate Polymers
Yifan DongNaru Zhao

Abstract

Sol-gel derived organic/inorganic hybrids, in which organic and inorganic components form co-networks at the molecular level, have demonstrated great potential for providing improved mechanical properties and biological functions in tissue engineering applications. Here, a novel bioactive hydroxyapatite-chitosan-silica hybrid (HA-CSH) scaffold was successfully fabricated by combining the sol-gel method and 3D plotting technique. Physiochemical characterization confirmed that chitosan was hybridized homogeneously with the inorganic phase on nanoscale. The obtained scaffolds possessed precisely controllable and interconnected porous structures. The nano-sized HA formed in situ and dispersed uniformly in the hybrid network, which reduced the water absorption and increased the mechanical strength of the hybrid scaffold under humidity condition as compared to chitosan-silica hybrid (CSH) scaffold. Compression tests showed that the 3D plotted hybrid scaffolds under wet conditions had compressive strengths of 10-13 MPa and elastic moduli of 21-27 MPa and thus met the mechanical requirements of human trabecular bone. Studies on the mineralization process under simulated body fluid (SBF) conditions confirmed that the introduction of HA ...Continue Reading

Citations

May 13, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jin-Ning LiangNa-Ru Zhao
Mar 25, 2021·Journal of Applied Biomaterials & Functional Materials·Blanca Elizabeth Monárrez-CorderoImelda Olivas-Armendáriz
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert Adamski, Dorota Siuta
May 5, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Jingjing ZhengLijun Ji
Jun 8, 2021·International Journal of Biological Macromolecules·L Roshini YadavN Selvamurugan

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