Fabrication of Pascal-triangle Lattice of Proteins by Inducing Ligand Strategy

Angewandte Chemie
Rongying LiuMing Jiang

Abstract

A protein Pascal triangle has been constructed as new type of supramolecular architecture by using the inducing ligand strategy that we previously developed for protein assemblies. Although mathematical studies on this famous geometry have a long history, no work on such Pascal triangles fabricated from native proteins has been reported so far due to their structural complexity. In this work, by carefully tuning the specific interactions between the native protein building block WGA and the inducing ligand R-SL, a 2D Pascal-triangle lattice with three types of triangular voids has been assembled. Moreover, a 3D crystal structure was obtained based on the 2D Pascal triangles. The distinctive carbohydrate binding sites of WGA and the intralayer as well as interlayer dimerization of RhB was the key to facilitate nanofabrication in solution. This strategy may be applied to prepare and explore various sophisticated assemblies based on native proteins.

References

Dec 1, 1991·The American Journal of Physiology·E R Weibel
Oct 29, 2000·Journal of Structural Biology·I ReviakineA Brisson
Feb 19, 2002·Chemical Reviews·Halina Lis, Nathan Sharon
Feb 21, 2002·Biochimica Et Biophysica Acta·Michiro MurakiKazuaki Harata
Oct 7, 2008·Accounts of Chemical Research·Michael O'KeeffeOmar M Yaghi
Feb 12, 2009·ACS Nano·Tsui-Fen ChouCarston R Wagner
Jun 6, 2009·Journal of the American Chemical Society·Shuvendu BiswasTakuzo Aida
Mar 3, 2010·Accounts of Chemical Research·Eric N SalgadoF Akif Tezcan
Oct 20, 2012·Chemical Communications : Chem Comm·Koji OohoraTakashi Hayashi
Jun 5, 2013·Current Opinion in Structural Biology·Bryan S Der, Brian Kuhlman
Jul 20, 2013·Journal of the American Chemical Society·Yushi BaiJunqiu Liu
May 17, 2014·Current Opinion in Biotechnology·François Baneyx, James F Matthaei
Aug 8, 2015·Chemical Communications : Chem Comm·Qiang SunWei Xu
Aug 11, 2015·Journal of the American Chemical Society·Jeffrey D BrodinF Akif Tezcan
Oct 28, 2015·ACS Nano·Xue ZhangYong-Feng Wang
Jan 23, 2016·Journal of the American Chemical Society·Guang YangMing Jiang
Apr 16, 2016·Chemical Society Reviews·Yushi BaiJunqiu Liu
Apr 30, 2016·Current Opinion in Structural Biology·Christoffer H Norn, Ingemar André
Aug 1, 2016·Current Opinion in Structural Biology·Todd O YeatesJoshua Laniado
Aug 9, 2016·Chemical Communications : Chem Comm·Xue ZhangYongfeng Wang
Sep 16, 2016·Nature·Po-Ssu HuangDavid Baker
May 20, 2017·Nature Communications·Zhilong JiangPingshan Wang
Jul 5, 2017·Angewandte Chemie·Zhilong JiangPingshan Wang
Dec 29, 2017·Journal of the American Chemical Society·Suyong ShinTae-Lim Choi
May 5, 2018·Science·Natalie ReznikovRoland Kröger
Oct 6, 2018·Journal of the American Chemical Society·Lei WangXiaopeng Li
Mar 22, 2019·Accounts of Chemical Research·Lingbo XingKai Wu
Jun 19, 2019·Nature Chemistry·Nancy E HernándezSagar D Khare

❮ Previous
Next ❯

Citations

Aug 19, 2021·Chemical Reviews·Jie ZhuF Akif Tezcan
Sep 28, 2021·Chemical Communications : Chem Comm·Yijia LiJunqiu Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
isothermal titration calorimetry
dynamic light scattering
atomic force microscopy
circular dichroism
AFM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

La Presse médicale
C MOULIN, A M MOULIN
Actualités odonto-stomatologiques
C Gysel
Journal of the American College of Cardiology
David S Bach
Computer Methods and Programs in Biomedicine
J J Reed
Genome Announcements
Jeffery D SnowdenGabriel F Kuty Everett
© 2021 Meta ULC. All rights reserved