Fabrication of PLG microspheres with precisely controlled and monodisperse size distributions

Journal of Controlled Release : Official Journal of the Controlled Release Society
Cory BerklandDaniel W Pack

Abstract

The size distribution of biodegradable polymer microspheres critically impacts the allowable routes of administration, biodistribution, and release rate of encapsulated compounds. We have developed a method for producing microspheres of precisely controlled and/or monodisperse size distributions. Our apparatus comprises spraying a polymer-containing solution through a nozzle with (i) acoustic excitation to produce uniform droplets, and (ii) an annular, non-solvent carrier stream allowing further control of the droplet size. We used this apparatus to fabricate poly(D,L-lactide-co-glycolide) (PLG) spheres. The acoustic excitation method, by itself, produced uniform microspheres as small as 30 microm in diameter in which > or =95% of the spheres were within 1.0-1.5 microm of the average. The carrier stream method alone allowed production of spheres as small as approximately 1-2 microm in diameter from a 100-microm diameter nozzle, but generated broader size distributions. By combining the two devices, we fabricated very uniform spheres with average diameters from approximately 5 to >500 microm. Furthermore, by discretely or continuously varying the experimental parameters, we fabricated microsphere populations with predefined size...Continue Reading

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Citations

Apr 10, 2010·Annals of Biomedical Engineering·Nathan H DormerMichael S Detamore
Mar 12, 2010·Journal of Materials Science. Materials in Medicine·Fuminori ItoKimiko Makino
Mar 21, 2007·Pharmaceutical Research·Cory BerklandKyekyoon Kevin Kim
Jun 15, 2004·Biomaterials·Xinming LiuJ-Y Jin-Ye Wang
Dec 20, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cory BerklandDaniel W Pack
Apr 6, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cory BerklandKyekyoon Kim
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cory BerklandDaniel W Pack
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Brett A AlmondEugene P Goldberg
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Sep 18, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qingxing XuDaniel W Pack
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