Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching

Materials Science & Engineering. C, Materials for Biological Applications
Soumyaranjan MohantyAnders Wolff

Abstract

Limitations in controlling scaffold architecture using traditional fabrication techniques are a problem when constructing engineered tissues/organs. Recently, integration of two pore architectures to generate dual-pore scaffolds with tailored physical properties has attracted wide attention in tissue engineering community. Such scaffolds features primary structured pores which can efficiently enhance nutrient/oxygen supply to the surrounding, in combination with secondary random pores, which give high surface area for cell adhesion and proliferation. Here, we present a new technique to fabricate dual-pore scaffolds for various tissue engineering applications where 3D printing of poly(vinyl alcohol) (PVA) mould is combined with salt leaching process. In this technique the sacrificial PVA mould, determining the structured pore architecture, was filled with salt crystals to define the random pore regions of the scaffold. After crosslinking the casted polymer the combined PVA-salt mould was dissolved in water. The technique has advantages over previously reported ones, such as automated assembly of the sacrificial mould, and precise control over pore architecture/dimensions by 3D printing parameters. In this study, polydimethylsilo...Continue Reading

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Citations

Feb 24, 2016·Biomacromolecules·Soumyaranjan MohantyJenny Emnéus
Oct 18, 2016·Journal of Biomedical Materials Research. Part a·J Mesquita-GuimarãesM C Fredel
Mar 3, 2018·Journal of Tissue Engineering and Regenerative Medicine·Viktoriia StarokozhkoMartin Dufva
Aug 16, 2017·Scientific Reports·Vincent Chi-Fung LiH Jerry Qi
Oct 7, 2018·Scientific Reports·Morteza RasoulianboroujeniLobat Tayebi
Oct 23, 2019·Materials·Michael SeidenstueckerAnke Bernstein
Jul 11, 2019·Current Transplantation Reports·Aylin AcunBasak E Uygun
May 1, 2021·Pharmaceuticals·Paula Gabriela ManitaManoli Igartua

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