Fabrication of tissue engineered osteochondral grafts for restoring the articular surface of diarthrodial joints

Methods : a Companion to Methods in Enzymology
Brendan L RoachAndrea R Tan

Abstract

Osteochondral allograft implantation is an effective cartilage restoration technique for large defects (>10 cm(2)), though the demand far exceeds the supply of available quality donor tissue. Large bilayered engineered cartilage tissue constructs with accurate anatomical features (i.e. contours, thickness, architecture) could be beneficial in replacing damaged tissue. When creating these osteochondral constructs, however, it is pertinent to maintain biofidelity to restore functionality. Here, we describe a step-by-step framework for the fabrication of a large osteochondral construct with correct anatomical architecture and topology through a combination of high-resolution imaging, rapid prototyping, impression molding, and injection molding.

References

Nov 1, 1990·Journal of Biomechanical Engineering·A W EberhardtV Vithoontien
Jan 1, 1985·Journal of Biomechanics·R HuiskesT J van Rens
May 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G A AteshianV C Mow
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·L E FreedG Vunjak-Novakovic
Jan 1, 1997·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·L HangodyI Udvarhelyi
Jan 7, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D A LeeD L Bader
Mar 12, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·G Vunjak-NovakovicL E Freed
Jun 29, 2000·The Journal of Bone and Joint Surgery. British Volume·H U StäubliW Rauschning
Oct 12, 2000·Biotechnology Progress·D PazzanoL J Bonassar
Dec 16, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C R LeeM Spector
Feb 24, 2001·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Y WengC A Vacanti
Apr 9, 2001·The American Journal of Sports Medicine·C S AhmadV C Mow
May 3, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S W O'DriscollJ S Fitzimmons
May 18, 2001·The New England Journal of Medicine·C A VacantiJ Shufflebarger
Jul 17, 2001·Cells, Tissues, Organs·S E FeinbergP H Krebsbach
Jul 27, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·G UndtR Ewers
Aug 31, 2001·Biochemical and Biophysical Research Communications·K J GoochL E Freed
Oct 18, 2001·Clinical Orthopaedics and Related Research·J R SteadmanJ J Rodrigo
Oct 4, 2002·Biomaterials·Jill K SherwoodAnthony Ratcliffe
Apr 8, 2003·Trends in Biotechnology·Vladimir MironovRoger R Markwald
Nov 15, 2003·Journal of Biomechanics·Clark T HungGerard A Ateshian
Jul 5, 2005·Clinical Orthopaedics and Related Research·Gerard A Ateshian, Clark T Hung
May 6, 2006·Tissue Engineering·Michael R Neidert, Robert T Tranquillo
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Felix EcksteinH Cecil Charles
Jul 3, 2008·Tissue Engineering. Part a·Jeffery J BallynsLawrence J Bonassar
Oct 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Warren L GraysonGordana Vunjak-Novakovic
Dec 5, 2009·The American Journal of Sports Medicine·Liming BianClark T Hung
Oct 5, 2010·Journal of Biomechanics·Jeffrey J Ballyns, Lawrence J Bonassar
Oct 30, 2013·Tissue Engineering. Part C, Methods·Bryan N BrownLawrence J Bonassar

❮ Previous
Next ❯

Citations

Feb 21, 2016·Journal of Biomechanics·Adam B NoverClark T Hung
Mar 10, 2016·Tissue Engineering. Part a·Brendan L RoachClark Tung-Hui Hung
Jun 29, 2015·Methods : a Companion to Methods in Enzymology·Gordana Vunjak-Novakovic
Oct 13, 2017·Toxicologic Pathology·Keiichi KurokiJames L Cook
Jun 25, 2016·Expert Opinion on Therapeutic Patents·Elena López-RuizMacarena Perán
Dec 29, 2016·Journal of Biomechanics·Miriam Chaudhary, Peter S Walker
Nov 13, 2017·ACS Biomaterials Science & Engineering·Grace O'ConnellJamali Amir

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.