Fabrication of transparent hemispherical 3D nanofibrous scaffolds with radially aligned patterns via a novel electrospinning method

Scientific Reports
Jeong In KimChan Hee Park

Abstract

Tissue engineering has significantly contributed to the development of optimal treatments for individual injury sites based on their unique functional and histologic properties. Human organs and tissue have three-dimensional (3D) morphologies; for example, the morphology of the eye is a spherical shape. However, most conventional electrospinning equipment is only capable of fabricating a two-dimensional (2D) structured fibrous scaffold and no report is available on a 3D electrospinning method to fabricate a hemispherical scaffold to mimic the native properties of the cornea, including microscopic to macroscopic morphology and transparency. We proposed a novel electrospinning method using a single nonconductive hemispherical device and a metal pin. A designed peg-top shaped collector, a hemispherical nonconductive device with a metal pin in the center and copper wire forming a circle around at the edge was attached to a conventional conductive collector. A 3D hemispherical transparent scaffold with radially aligned nanofibers was successfully fabricated with the designed peg-top collector. In summary, our fabricated 3D electrospun scaffold is expected to be suitable for the treatment of injuries of ocular tissues owing to the he...Continue Reading

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Citations

Nov 19, 2018·Cardiovascular Toxicology·Gaurav TanejaArun K Sharma
Jul 23, 2020·Tissue Engineering and Regenerative Medicine·S Sharareh MahdaviAli R Djalilian
Nov 12, 2019·Bioactive Materials·Maria P Nikolova, Murthy S Chavali
Nov 11, 2019·Advanced Drug Delivery Reviews·Fitsum Feleke SahleTao L Lowe
Mar 2, 2021·Journal of Tissue Engineering·Mohit ParekhHannah J Levis
Apr 20, 2021·Experimental Eye Research·Andrey Yurevich AndreevSergey Petrovich Domogatsky
Jan 20, 2021·ACS Biomaterials Science & Engineering·Ankush DewleAkshay Srivastava
Aug 28, 2021·International Journal of Pharmaceutics·Raúl Cazorla-LunaDimitrios A Lamprou

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Methods Mentioned

BETA
scanning electron microscopy
Assay
DNA assay
PCR
electrophoresis
Confocal microscopy
Fluorescence

Software Mentioned

COMSOL®

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